Genomics research should not stop at obtaining information from genome sequences or epigenetic modifications. An in-depth exploration of three-dimensional chromatin folding is also essential for understanding genome functions. In the past ten years, the advancement of high-throughput sequencing technology and the development of high-resolution imaging technology have made the complex three-dimensional structure of the genome increasingly clearly presented in front of people. Among them, Topologically Associated Domains (TADs) discovered by…