Structurally Reveals the Mechanism of Calpain Inhibitor Dual Inhibition of the New Coronavirus Main Protease and Human Cathepsin L

SARS-CoV-2 is a respiratory virus that causes COVID-19 disease. It attacks the human body through multiple steps. Entering cells deep in the lungs and hijacking the molecular machinery of human host cells to produce copies of the virus itself are the first two steps – both of these steps are essential for virus infection.   In a new study, researchers from the University of Arizona and the University of South…

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Nature: A Human Antibody Can Potently Neutralize Multiple Coronaviruses Including Sars-Cov and Sars-Cov-2

In a new study, researchers from the Swiss Humbs Biomed SA and the University of Washington found an antibody identified for the first time in blood samples from a patient with the severe acute respiratory syndrome (SARS, commonly known as atypical pneumonia) in 2003 which can inhibit related coronaviruses, including the new coronavirus SARS-CoV-2 that causes 2019 coronavirus disease (COVID-19). This antibody, called S309, is currently in rapid development and…

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