Label-free Single Molecule Optical Imaging Based on Surface Plasmon Resonance Microscope

Single-molecule optical imaging can analyze the morphology and function of a single molecule, so it can not only provide statistical average information of multiple molecules, but also provide single-molecule individual difference information that traditional biosensors cannot provide, allowing us to observe and understand the nature and function of the molecule in the more detail.   The research team of Professor NJ Tao and Professor Shaopeng Wang of the Bioelectronics and…

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The High-resolution Structure of de novo DNA Methyltransferase and Natural Substrate Nucleosomes

Recently, the Xu Huaqiang group of the Shanghai Pharmaceutical Research Institute, Chinese Academy of Sciences, in cooperation with the Peter Jones group and Karsten Melcher group of the US Van Andel Research Institute, used cryo-electron microscopy to analyze the high-resolution structure of the de novo DNA methyltransferase (DNMT3A2/DNMT3B3) and the natural substrate nucleosome. Research describes the binding mode of DNMT3A2/DNMT3B3 and the nucleosome, and proposes a model of genome-wide DNA…

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The Activity of TCP Family Transcription Factors Is Associated with Changes in the 3D Conformation of Chromatin

Genomics research should not stop at obtaining information from genome sequences or epigenetic modifications. An in-depth exploration of three-dimensional chromatin folding is also essential for understanding genome functions. In the past ten years, the advancement of high-throughput sequencing technology and the development of high-resolution imaging technology have made the complex three-dimensional structure of the genome increasingly clearly presented in front of people. Among them, Topologically Associated Domains (TADs) discovered by…

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Near-infrared Zone II Fluorescence Imaging Technology and Its Prospects in Biomedical Applications

Fluorescence imaging technology has broad application prospects in basic biomedical research and clinical diagnostic testing. Near-infrared zone II fluorescence (1000-1700nm, NIR-II) imaging technology overcomes the strong tissue absorption, scattering, and autofluorescence interference faced by traditional fluorescence (400-900nm), and can achieve higher tissue penetration depth in vivo imaging with time and space resolution, it is regarded as the most promising next-generation in vivo fluorescence imaging technology.   Wang Qiangbin, a researcher…

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Scientists Develop EM-visible Labeling Technology to Achieve Precise Positioning of Cell Single Molecules

For a full 10 years since returning to China in 2010, He Wanzhong, a researcher at the Beijing Institute of Biological Sciences, finally found a light in the darkness and handed in a satisfactory answer to himself and his supporters.   This light is that he led the team to originally developing a new type of visible electron microscopy(EM) labeling technology, which can directly synthesize gold nanoparticles in situ on…

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Progress on Photoacoustic Molecular Imaging in Diagnosis and Treatment of Rheumatoid Arthritis

Recently, the team of Liu Chengbo, the associate researcher of the Biomedical Optics and Molecular Imaging Laboratory of the Institute of Medical Engineering, and the team of Zhang Peng, a researcher of the Center for Translational Medicine, and the team of Professor Ding Dan of Nankai University have collaborated in the light acoustic molecular imaging research and a breakthrough has been made in this area. The research is based on…

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A Comprehensive Summary of the Harmful Effects of COVID-19 on Organs Other Than the Lungs

At the beginning of the outbreak of the new coronary pneumonia in New York City, Aakriti Gupta, MD, after only a few days of caring for critically ill patients, realized that this is far more than just a respiratory disease.   “I’ve been on the front line from the beginning. I have observed that patients clot a lot, even if they don’t have diabetes, they also have high blood sugar,…

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Advances in Research on Multi-modal Imaging Tracing for Drug Delivery

Cancer is a major disease that threatens human life and health, and drug therapy (chemotherapy) is one of the effective means to treat cancer. In order to further improve the efficacy and reduce toxic and side effects, the targeted delivery and precise release of anti-cancer drugs have become an important content of anti-cancer drug development. However, how to accurately trace the delivery process, targeted drug release process, and biodistribution and…

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A Detailed 3D Model of SARS-COV-2 Created!

As countries around the world race to learn about the SARS-CoV-2 virus that caused the 2019 coronavirus disease (COVID-19) pandemic, scientists have gained more and more information about the viral components that make up infectious particles.   Although every new discovery about SARS-CoV-2 provides scientists and governments with important new information, none of them can provide a clear overview of the virus particles.   Now, the cooperation between experts has…

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Brain Imaging Reveals the Mysteries of Aging

In a recent study, scientists took the first overall color picture of mice of different ages, which is an important step in understanding individual behavior. The results of the study, published in the journal Science, are key to revealing the mechanisms of learning disabilities, dementia, and how memory is affected by age.   Synapses are important connections between brain cells to transmit electrical and chemical information. Synapse damage is associated…

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