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BUB1 Protein Crystal

(CBCRY01)  Download Datasheet
Background
Background
The kinase(BUB1) functions in part by phosphorylating a member of the miotic checkpoint complex and activating the spindle checkpoint. Mutations in this gene have been associated with aneuploidy and several forms of cancer.
Molecular Description
Protein Classification
Transferase
Structure Weight
42450.29 Da
Polymer
1
Molecule
Mitotic checkpoint serine/threonine-protein kinase BUB1
Chain Length
365 amino acids
Crystal Description
PDB ID
3E7E
MMDB ID
68144
Source
Spodoptera frugiperda
Method
X-Ray Diffraction
Resolution
2.31 Å
Ligand Chemical Component
Adenosine-5'-triphosphate; chloride ion; Magnesium ion
Gene Information
Gene Name
BUB1
Synonyms
BUB1A, BUB1L, hBUB1, BUB1 budding uninhibited by benzimidazoles 1 homolog; budding uninhibited by benzimidazoles 1; mitotic spindle checkpoint kinase; putative serine/threonine-protein kinase
UniProt ID
O43683
Gene ID
699
Chromosome Location
2q14
Function
nucleotide binding; protein kinase activity; protein serine/threonine kinase activity ; ATP binding; kinase activity; transferase activity
Reference
Reference
Kang J, Yang M, Li B, Qi W, Zhang C, Shokat KM, Tomchick DR, Machius M, Yu H. Structure and substrate recruitment of the human spindle checkpoint kinase Bub1.Mol Cell. 2008 Nov 7;32(3):394-405.