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NMR Services

NMR spectroscopy is a key analytical technique for structure elucidation of a wide range of materials from small molecules to compounds. The technique provides detailed molecular information that allows researchers have in-depth understanding of composition, chemical structure, morphology, and dynamics. NMR is particularly useful in analysis of pharmaceuticals, screening weak-binding compounds and developing into drug-like inhibitors for drug discovery. Supported by our NMR platform, Creative Biostructure offers high quality customized services ranging from production of labeled-proteins to acquisition and analysis of high-field NMR data for researchers in science and pharmaceutical industry.

NMR Services


NMR workflow


NMR services capabilities

Why Creative Biostructure?
State-of-the-art instruments
Senior scientists with extensive exerience
Rapid turnaround time

Sample preparation guideline

  • Labeling with isotopes: Protein NMR spectroscopy requires isotope enrichment, such as 15N, 13C, 31P, 19F in common. Samples with other isotope are also acceptable.
  • Size: The molecular weight of biomacromolecule of a NMR sample is typically less than 50 KDa for high-resolution structure elucidation. Larger proteins or complexes can be studied to identify ligand/drug-binding site or to characterize the physical state.
  • Amount: For solution NMR, a sample typically contains 1-10 mg/ml or 0.3 mM purified protein in a suitable buffer; for solid-state NMR, we require larger amount of samples, please talk to our specialist for more information.
  • Stability: For most in-depth studies by NMR, the protein needs to be stable for several days at room temperature for data acquisition.

Please contact us to discuss your particular project.

Ordering Process

Ordering Process

Reference
Xiao S., Capelluto D., (2015). Tom1 modulates binding of Tollip to phosphatidylinositol 3-Phosphate via a coupled folding and binding mechanism. Structure, 23: 1910-1920