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GPD1 Protein Crystal

(CBCRY30)  Download Datasheet
Background
Background
Homo sapiens L-alpha-glycerol-3-phosphate dehydro-genase 1 (GPD1) catalyzes the reversible biological conversion of dihydroxyacetone (DHAP) to glycerol-3-phosphate. The GPD1 protein was expressed in Escherichia coli, and purified as a fusion protein with glutathione S-transferase.
Molecular Description
Protein Classification
Oxidoreductase
Structure Weight
39164.02 Da
Polymer
1
Molecule
Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic
Chain Length
354 amino acids
Crystal Description
PDB ID
1X0X
MMDB ID
38469
Source
E.coli
Method
X-Ray Diffraction
Resolution
2.75Å
Ligand Chemical Component
NAD; Sulfate ion
Gene Information
Gene Name
GPD1
Synonyms
FLJ26652; glycerol-3-phosphate dehydro-genase, soluble; glycerol-3-phosphate dehydrogenase 1 (soluble); EC 1.1.1.8; GPD-C; GPDH-C
UniProt ID
P21695
Gene ID
2819
Chromosome Location
12q12-q13
Function
NAD or NADH binding; binding; glycerol-3-phosphate dehydrogense (NAD+) activity; glycerol-3-phosphate dehydrogense activity; protein homodimerization activity
Reference
Reference
Ou, X., Ji, C., Han, X., Zhao, X., Li, X., Mao, Y., Wong, L.L., Bartlam, M., Rao, Z. (2006) Crystal Structures of Human Glycerol 3-phosphate Dehydrogenase 1 (GPD1) J.Mol.Biol. 357: 858-869