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GSK3b Protein Crystal

(CBCRY47)  Download Datasheet
Background
Background
Glycogen synthase kinase-3 beta is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. It acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1.
Molecular Description
Protein Classification
Transferase
Structure Weight
93983.28 Da
Polymer
1
Molecule
GLYCOGEN SYNTHASE KINASE-3 BETA
Chain Length
420 amino acids
Crystal Description
PDB ID
1I09
MMDB ID
18277
Source
Unidentified baculovirus
Method
X-Ray Diffraction
Resolution
2.70 Å
Ligand Chemical Component
PO4-
Gene Information
Gene Name
GSK3B
Synonyms
Serine/threonine-protein kinase GSK3B
UniProt ID
P42574
Gene ID
2932
Chromosome Location
3q13.3
Function
ATP binding; beta-catenin binding; kinase activity; NF-kappaB binding; p53 binding; protein kinase A catalytic subunit binding; protein kinase binding; protein serine/threonine kinase activity; RNA polymerase II transcription factor binding
Reference
Reference
Ter Haar E, Coll JT, Austen DA, Hsiao HM, Swenson L, Jain J. Structure of gsk3beta reveals a primed phosphorylation mechanism. Nat.Struct.Biol. (2001) 8 p.593