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MARK1 Protein Crystal

(CBCRY40)  Download Datasheet
Background
Background
The microtubule-associated protein (MAP)/microtubule affinity regulating kinase (MARK)/Par-1 phosphorylates microtubule-associated proteins tau, MAP2, and MAP4 and is involved in the regulation of microtubule-based transport. There are four isoforms of MARK in the human kinome that form a subfamily of the Snf1/AMP-activated protein kinase family of kinases within the calcium/calmodulin-dependent protein kinase group. MARK kinases are relatively large; the longest isoform, MARK1, comprises 795 amino acids. It is involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. MARK1 also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).
Molecular Description
Protein Classification
Signaling Protein, Transferase
Structure Weight
301702.41 Da
Polymer
1
Molecule
Serine/threonine-protein kinase MARK1
Chain Length
328 amino acids
Crystal Description
PDB ID
2HAK
MMDB ID
40554
Source
E.coli
Method
X-Ray Diffraction
Resolution
2.60 Å
Gene Information
Gene Name
MARK1
Synonyms
KIAA1477, MARK
UniProt ID
Q9P0L2
Gene ID
4139
Chromosome Location
1q41
Function
ATP binding; magnesium ion binding; phosphatidic acid binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylserine binding; protein serine/threonine kinase activity; tau-protein kinase activity
Reference
Reference
Marx A, Nugoor C, Mueller J, Panneerselvam S, Timm T, Bilang M, Mylonas E, Svergun DI, Mandelkow E-, Mandelkow EJ.Biol.Chem. Structural variations in the catalytic and ubiquitin-associated domains of microtubule-associated protein/microtubule affinity regulating kinase (Mark) 1 and mark2. (2006) 281 p.27586