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NTF3 with NGFR Protein Crystal

(CBCRY18)  Download Datasheet
Background
Background
Neurotrophins (NTs) are important regulators for the survival, differentiation and maintenance of different peripheral and central neurons. NTs bind to two distinct classes of glycosylated receptor: the p75 neurotrophin receptor (p75(NTR)) and tyrosine kinase receptors (Trks). Whereas p75(NTR) binds to all NTs, the Trk subtypes are specific for each NT.
Molecular Description
Protein Classification
signaling protein
Structure Weight
63861.22 Da
Polymer
1
Molecule
Neurotrophin-3
Chain Length
119 amino acids
Polymer
2
Molecule
Tumor necrosis factor receptor superfamily member 16
Chain Length
167 amino acids
Crystal Description
PDB ID
3BUK
MMDB ID
65479
Source
E.coli
Method
X-Ray Diffraction
Resolution
2.6Å
Ligand Chemical Component
N-Acetyl-D-Glucosamine
Gene Information
Gene Name
NTF3
Synonyms
HDNF; MGC129711; NGF-2; NGF2; NT3; Nerve growth factor 2; neurotrophic factor; neurotrophin 3
UniProt ID
P20783
Gene ID
4908
Chromosome Location
12p13
Function
growth factor activity; nerve growth factor binding; neurotrophin receptor binding
Gene Name
NGFR
Synonyms
CD271; Gp80-LNGFR; TNFRSF16; p75(NTR); p75NTR; low affinity nerve growth factor receptor; low-affinity nerve growth factor receptor; nerve growth factor receptor; CD271 antigen; NGF receptor; nerve growth factor receptor
UniProt ID
P08138
Gene ID
4804
Chromosome Location
17q21-q22
Function
death receptor activity; nerve growth factor binding; protein binding
Reference
Reference
Gong, Y., Cao, P., Yu, H.J., Jiang, T. (2008) Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex. Nature 454: 789-793