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PDE10A Protein Crystal

(CBCRY50)  Download Datasheet
Background
Background
Phosphodiesterase 10A belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate.
Molecular Description
Protein Classification
Hydrolase
Structure Weight
76792.17 Da
Polymer
1
Molecule
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Chain Length
331 amino acids
Crystal Description
PDB ID
2OUP
MMDB ID
45267
Source
E.coli
Method
X-Ray Diffraction
Resolution
1.56 Å
Ligand Chemical Component
Mg2+ Zn2+
Gene Information
Gene Name
PDE10A
Synonyms
HSPDE10A
UniProt ID
Q9Y233
Gene ID
10846
Chromosome Location
6q26
Function
3',5'-cyclic-GMP phosphodiesterase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; cAMP binding; cGMP binding; metal ion binding
Reference
Reference
Wang H, Liu Y, Hou J, Zheng M, Robinson H, Ke H. From the cover: structural insight into substrate specificity of phosphodiesterase 10. Proc.Natl.Acad.Sci.Usa (2007) 104 p.5782