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Mempro™ Liposome in Drug Delivery

Creative Biostructure has established a novel and comprehensive Mempro™ Liposome platform in the past years. Because of the versatility and ability to play as targeted release-on-demand carrier vehicles for both water-soluble and oil-soluble materials, Mempro™ Liposome Technology has been adopted as a powerful tool in a variety of industrial applications. One of the first and most important applications of liposomes is to encapsulate drugs and therapeutics in order to achieve localized delivery. Liposome is very effective in drug delivery because they are able to incorporate a series classes of substances such as anticancer drugs, antiviral, antibacterial, hormones, enzymes, steroids, nucleotides, peptides, proteins and bronchodilators.

Figure 1. Liposomes has been modified by AG73 for syndecan 2 to target the edelfosine. AG73-PEG2KLipo for targeting edelfosine to syndecan 2 on cancer cells is depicted. (G. Shim, et al., 2016) Figure 1. Liposomes has been modified by AG73 for syndecan 2 to target the edelfosine. AG73-PEG2KLipo for targeting edelfosine to syndecan 2 on cancer cells is depicted. (G. Shim, et al., 2016)

The main purpose of liposomal drug delivery is to make the active compounds highly localized at disease sites such as tumors and inflammations. As reuslts of the changes occured in liposomal structures or their reactivity, localization is the controlled release which promotes the release of encapsulated materials. Release of the target-drug at the target sites is ensuered by controlled release through a specific mechanism. There are two major controlled-release mechanisms. One is based on the development of an affinity reaction between the target and the liposome, The other one is a triggered-release and involves incorporating an environmentally-responsive (pH, temperature change, or light irradiation) molecule into the liposome that will cause structural changes in the bilayer membrane. Alteration of liposome surface charge has also been shown to enhance drug entrapment and release.

There are some liposomal drug delivery applications as below:

  1. Drugs, such as Amphotericin-B, Paclitaxels, Minoxidil, and Cyclosporins, are have a enhanced solubility by using liposomes;
  2. Sensitive drug molecules, like cytosine arabinosa, DNA, RNA, antisense oligo-nucleotides, and ribozymes, can be protected from degradation;
  3. Intracellular uptake of drugs have increased;


For example, respiratory disorders have been treated with liposomal aerosols in order to reduce the toxicity, have a sustained-release effect, prevent local irritation, and improved stability. These aerosols can treat various eye diseases such as dry eyes, keratitis, uveitis, corneal transplant rejection, endopthelmitis, and proliferative vitro retinopathy by being used as a vector for genetic transfection and monoclonal antibody directed vehicles. Liposomes can also applied as anti-infective agents to remove pathogens reside in the human body. Small and stable liposomes can target different tumors since they can circulate longer and pass through vessel walls into surrounding tissues through enhanced vascular permeability improving anticancer therapy.

Besides drug delivery, Mempro™ Liposome Technology has also been used in a wide variety of applications such as cosmetics, encapsulations, food industry, cancer therapy, and gene therapy, etc. Please feel free to contact us for a detailed quote.

References:
S. R. Paliwal, et al. (2016). Hyaluronic acid modified pH-sensitive liposomes for targeted intracellular delivery of doxorubicin. Journal of Liposome Research, 26(4): 276-287.
A. Bunker. et al. (2016). Rational design of liposomal drug delivery systems, a review: Combined experimental and computational studies of lipid membranes, liposomes and their PEGylation. Biochimica et Biophysica Acta, 1858: 2334-2352.
G. Shim, et al. (2016). Surface-modified liposomes for syndecan 2–targeted delivery of edelfosine. Asian Journal of Pharmaceutical Sciences, 11(5): 596-602.


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