The rapid development of instrument and data processing technology, especially the invention of electron microscopy, has brought great help to obtain the ultrastructure of viral particles. Equipped with state-of-the-art optical microscopy, electron microscopy, and powerful data processing software, Creative Biostructure can provide visualization services for coronavirus-like particles based on a variety of technologies.
Coronaviruses (CoVs) have led to two major outbreaks of human fatal pneumonia since the beginning of the 21st century. The Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) broke out in 2003 and spread to five continents with a lethal rate of 10%. And the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) broke out in the Arabian Peninsula in 2012 with a lethal rate of 35%. SARS-CoV-2 (provisionally named 2019-nCoV) is a novel coronavirus that leads to an outbreak of respiratory illness termed as Coronavirus Disease 2019 (COVID-19), which has spread to many countries around the world.
Figure 1. Electron microscope image of SARS-CoV. (Photo courtesy of CDC.gov)
With the assistant of instruments, we can easily obtain biophysical information of viral particles, which supports identification and characterization of virus in a directly visualized manner, as well as to screen important components during the viral infection process. At present, scientists have obtained several electron microscopic images of SARS-CoV-2 virions. Thanks to our professional structural biology technologies, Creative Biostructure can provide a variety of services based on electron microscopy and super-resolution optical microscopy, including but not limited to: