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ALB Protein Crystal(CBCRY36)

Product Summary
Name ALB Protein Crystal Download Datasheet
Background
Background 3'-Azido-3'-deoxythymidine (AZT) is the first clinically effective drug for the treatment of human immunodeficiency virus infection. The drug interaction with human serum albumin (HSA) has been an important component in understanding its mechanism of action, especially in drug distribution and in drug-drug interaction on HSA in the case of multi-drug therapy.
Molecular Description
Protein ClassificationLipid binding protein
Structure Weight68485.53 Da
Polymer1
MoleculeSerum albumin
Chain Length585 amino acids
Crystal Description
PDB ID3B9M
MMDB ID64671
SourceE.coli
MethodX-Ray Diffraction
Resolution2.70Å
Ligand Chemical ComponentAZZ; Myristic acid; 2-hydroxybenzoic acid
Gene Information
Gene NameALB
SynonymsDKFZp779N1935; PRO0883; PRO0903; PRO1341; cell growth inhibiting protein 42; growth-inhibiting protein 20; serum albumin
UniProt IDP02768
Gene ID213
Chromosome Location4q11-q13
FunctionDNA binding; fatty acid binding; copper ion binding; protein binding; drug binding; lipid binding; toxin binding; antioxidant activity; oxygen binding; pyridoxal phosphate binding; metal ion binding
Reference
Reference Zhu, L., Yang, F., Chen, L., Meehan, E.J., Huang, M. (2008) A new drug binding subsite on human serum albumin and drug-drug interaction studied by X-ray crystallography J.Struct.Biol. 162: 40-49

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