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Publications, Patents, and Book Chapters Citing Our Work

We provided high-quality service to numerous customers. A long list of papers have been published in Peer-reviewed Publications journals and a lot of patent applications have been approved or in process with custom products or services from us. Below are some selected patents and papers to give you an idea of how our products and custom services have been applied as part of leading edge in life science research in academia and industry. These publications are sorted according to different divisions of our company.

Title Author Year Journal Description Related Services/Products
Nutritional supplement containing a nuclear fraction of bovine thymus gland increases the circulating levels of spermidine Surzenko N, Dominique A, et al. 2025 Plos one … We would like to thank Creative Biostructure for their help in detecting and characterizing the liposomes and their content … Cryo-EM for Particle Morphology Analysis
High-Performance Liquid Chromatography (HPLC)
Advances in magnetic affinity-based isolation/detection of exosomes for robust diagnostics Solovicová V, Ďatková A, et al. 2025 Microchimica Acta … Isolation of exosomes using microfluidic-based devices can be performed in a form of a service provided by the companies Creative Biostructure … Microfluidics-Based Exosome Isolation Service
Pharmaceutical Chemistry Innovations FATIMA T, SHABBIR S. 2025 Advances in Chemical Sciences … QSAR Analysis: Creative Biostructure Drug Discovery … QSAR Analysis
A VLPs based vaccine protects against Zika virus infection and prevents cerebral and testicular damage Côrtes N, Lira A, et al. 2025 npj Vaccines … The QβVLPs construction was made by Creative Biostructure (USA)… Virus-like Particle Construction
Nanotechnology for the Efficacious Delivery of Medicinal Cannabis and Pharmaceutical Medicines Vitetta L, Henson J D, et al. 2025 Pharmaceuticals … Creative Biostructure, Shirley, NY, USA Lipo-308C [CBD] Cannabis sativa extract… Active Cannabis Sativa Extract Liposome(Lipo-308C)
Extracellular vesicle miRNA signatures in pediatric onset-multiple sclerosis and obesity-driven immune and metabolic dysregulation Hade M D, Reátegui E, et al. 2025 medRxiv … RNA isolation, miRNA sequencing and bioinformatics were conducted by Creative Biostructure (Shirley, NY, USA)… Exosomal Small RNA and miRNA Sequencing Service
Effects of Lipid Headgroups on the Mechanical Properties and In Vitro Cellular Internalization of Liposomes Xu J, Adepoju S, et al. 2025 Langmuir … Liposome Applications, Creative Biostructure… Liposome Applications
A Novel and Reliable Analysis Method Utilizing Hennosides to Improve the Quality Assessment of Lawsonia inermis L. Material Used in Cosmetic Formulations Dallmann N, Vill V, Straske F. 2025 Cosmetics … All NMR experiments were performed by Creative BioStructure (Shirley, NY, USA)… NMR Spectroscopy Services
Unlocking the Secrets of Protein Misfolding: AlphaFold’s Role in Cardiovascular Disease Leyva R S. 2024 Berkeley Scientific Journal … X-ray crystallography process: From crystal to protein model. Creative Biostructure… X-ray Crystallography Platform
Evolution of the clinical-stage hyperactive TcBuster transposase as a platform for robust non-viral production of adoptive cellular therapies Skeate J G, Pomeroy E J, et al. 2024 Molecular Therapy … Plasmids containing individual point mutations were obtained from Creative Biostructure from a failed attempt to shuffle the mutations… Custom Library Design and Construction Service
Nanodisc assembly from bacterial total lipid extracts Llewellyn, Trent R., et al. 2024 Chemistry and Physics of Lipids … In collaboration with Creative BioStructure (Shirley, NY, USA), the FEI Talos F200C Cryo-Transmission Electron Microscope was used to analyze one nanodisc sample … Cryo-EM for Particle Morphology Analysis
Multiplexed electrical detection of whole viruses from plasma in a microfluidic platform Jankelow, Aaron, et al. 2024 Analyst … B19V virus-like particles (VLPs) (Cat# CBS-V088-C) were obtained from Creative BioStructure … Parvovirus B19 VLP (VP1, VP2) Co-Capsid
Offline preparative separation methods based on electromigration: An overview and current trends Hrušková, H.,Řemínek, R. and Foret, F. 2024 TrAC Trends in Analytical Chemistry … Commercial free-flow electrophoretic instruments, e.g., Free-Flow electrophoresis systems marketed by FFE Service GmbH (Feldkirchen, Germany) or Creative BioStructure (Shirley, NY, USA) … Mempro™ Free Flow Electrophoresis (FFE)
APOE Christchurch-mimetic therapeutic antibody reduces APOE-mediated toxicity and tau phosphorylation Marino, Claudia, et al. 2024 Alzheimer's & Dementia ... Recombinant Fab region including the complementarity-determining regions (CDRs) of the 7C11.chIgG1 antibody was produced as fee-for-service by Creative BioStructure (Shirley, NY, USA) ...Binding kinetics between the purified Fab-7C11 protein and recombinant ApoE4 were quantified in PBS solution using a Biacore 3000 instrument (GE Healthcare) as a fee-for-service with Creative BioStructure and according to previously published procedures ...We resolved the three-dimensional crystal structure of purified 7C11.IgGFab protein as a fee-for-service with Creative BioStructure … Custom Protein Production, Surface Plasmon Resonance (SPR), X-ray Crystallography Services
A self-adjuvanted VLPs-based Covid-19 vaccine proven versatile, safe, and highly protective Vuitika, Larissa, et al. 2024 Scientific Reports … synthetic E. coli plasmid of the QβVLPs was constructed by Creative BioStructure (Ramsey Road Shirley, NY 11967, USA), cloning the CP gene from Qβ bacteriophage into pET28a(+) without a 6x-His tag ... Virus-like Particle Construction
Initial Exploration of the In Vitro Activation of GLP-1 and GIP Receptors and Pancreatic Islet CellProtection by Salmon-Derived Bioactive Peptides Currie, C., Bjerknes, C. and Framroze, B. 2024 Marine Drugs … Peptide fractionation was undertaken by Creative BioStructure (45–1 Ramsey Road, Shirley, New York, 11967, USA) ... Protein Purification
Marine-derived sea urchin compounds as potential anti-cancer drug candidate against colorectal cancer: In silico and in vitro studies Molla, M.H.R. and Aljahdali, M.O. 2023 Saudi Journal of Biological Sciences ... Easily predicting the hydrophobicity, solubility, permeability, etc. of substances and applying predictive models for blood–brain barrier (BBB) permeability, medication bioavailability, cytochrome P450, hERG toxicity, and more are possible using Creative Biostructure … ADME-Tox Modeling and Prediction
Purification, crystallization, and preliminary structural analysis of multivalent immunogenic effector protein-anchored SARS-CoV-2 RBD Kwon, T.H. and Kim, T.G. 2023 bioRxiv … Crystallization BmRecA-RBD protein was initially crystallized using various screening kits from commercial company as Hampton Research, Creative BioStructure … Optimization of Screening Kits and Reagents
Inhibition of α-hemolysin activity of Staphylococcus aureus by theaflavin 3, 3’-digallate Goc, Anna, et al. 2023 Plos one … To determine binding affinity of native Hla with TF3, SPR binding assay was performed (Creative BioStructure, Shirley, NY)… Surface Plasmon Resonance (SPR)
Phytochemicals and micronutrients in suppressing infectivity caused by SARS-CoV-2 virions andseasonal coronavirus HCoV-229E in vivo Goc, Anna, et al. 2023 European Journal of Microbiology and Immunology … SARS-CoV-2 viral like particles (VLPs) were obtained from Creative BioStructure (Shirley, NY, USA) … SARS-CoV-2 VLP Products
A novel mechanism of herbicide action through disruption of pyrimidine biosynthesis Kang, IL-Ho, et al. 2023 Proceedings of the National Academy of Sciences … Creative BioStructure (Shirley, NY) provided the X-ray crystallographic support … X-ray Crystallography Services
A Self-Emulsified Adjuvant System Containing the Immune Potentiator Alpha Tocopherol Induces Higher Neutralizing Antibody Responses than a Squalene-Only Emulsion When Evaluated with a Recombinant Cytomegalovirus (CMV) Pentamer Antigen in Mice Lodaya, Rushit N., et al. 2023 Pharmaceutics … To understand the morphology of the oil droplets in SE-AS44 compared to AS03, we collaborated with Creative BioStructure (Shirley, NY, USA) to obtain cryo-EM images and size … Cryo-EM for Particle Morphology Analysis
A Review on Liposomes as a Drug Delivery System Somasundaram, Dr N. 2023 International Journal of Pharmacy and Analytical Research(IJPAR) ... Known for high performance and efficient development in liposome delivery systems, Creative BioStructure has extendedthe applications into the cosmetic industry … Liposome Products
Dual-clamped one-pot SERS-based biosensors for rapid and sensitive detection of SARS-CoV-2 using portable Raman spectrometer Kaladharan, Kiran, et al. 2023 Sensors and Actuators B: Chemical … SARS-CoV-2 VLP protein was obtained from Creative BioStructures (New York, USA)... SARS-CoV-2 VLP Products
Broad-spectrum virus trapping with heparan sulfate-modified DNA origami shells Monferrer, Alba, et al. 2022 ACS nano … VLPs were purchased from Creative BioStructure … HPV16 VLP (L1 Proteins)
Yeast nicotinate-nucleotide pyrophosphorylase in complex with ligand: crystallization and preliminary structural approaches Kim, Tae Gyun, et al. 2022 Biodesign … Apo NMnPP protein was initially crystallized using various screening kits from commercial company as Hampton Research, Creative BioStructure … Optimization of Screening Kits and Reagents
Linoleic acid binds to SARS-CoV-2 RdRp and represses replication of seasonal human coronavirus OC43 Goc, Anna, et al. 2022 Scientific Reports ... SPR binding assay, which measures binding affinity KD as well kinetic parameters ka and kd of human RdRp protein, withLA as the ligand, was utilized, where RdRp protein was printed onto the chip and the analyte was LA at different concentrations (Creative Biostructure, Shirley, NY) ...It is a complex structure of SARS-CoV-2 RNA polymerase with double-strand RNA fragments (Creative BioStructure, Shirley, NY) … Surface Plasmon Resonance (SPR), Molecular Docking
AI in Proteomics: A Comparison Between Crystallographic and in silico Methods of Protein Modeling Weissman, Alex D. 2022 Honors Theses … Our purified samples of NSP4 were then sent to Creative BioStructure for crystallization condition determination … X-ray Crystallography Services
Rapid quality control assessment of adeno-associated virus vectors Via stunner Yang, Quan-En, et al. 2022 GEN Biotechnology … Empty versus full viral particle assays by TEM were performed by Creative BioStructure … Cryo-EM for Viral Particle Identification and Characterization
Nanoliposomes, from food industry to nutraceuticals: Interests and uses Bondu, C. and Yen, F.T. 2022 Innovative Food Science & Emerging Technologies … which manufactures food supplements from marine oil rich in omega 3, as well as Creative BioStructure which custom produces liposomes … Liposome Production
Optical technologies for the detection of viruses like COVID-19: Progress and prospects Lukose, J., Chidangil, S. and George, S.D. 2021 Biosensors and Bioelectronics … Creative BioStructure has been using their commercial SPR systems to evaluate the binding affinity between SARS-CoV-2 S protein and human ACE2 receptors … Surface Plasmon Resonance (SPR)
Characterization and fine structure of exosomes Al-shubaily, F.A. and Al-Zahrani, M.H. 2021 Role of Exosomes in Biological Communication Systems … Creative BioStructure provides a sensitive technology for exosome characterization to gain more information and accelerating the use of exosome biology in diagnostic tests or clinical … Exosome Characterization Services
Methods for enzyme library creation: Which one will you choose? A guide for novices and experts to introduce genetic diversity Alejaldre, L., Pelletier, J.N. and Quaglia, D. 2021 BioEssays … Other companies that offer library generation services include Creative BioStructure … Custom Library Design and Construction Service
Sizing extracellular vesicles using membrane dyes and a single molecule-sensitive flow analyzer Andronico, Luca A., et al. 2021 Analytical chemistry … For selection of membrane dye, we used big liposomes (B-Lipo, from Creative BioStructure; DOPC:CHOL 55:45 mol/mol)whose distribution was centered at 130 nm ... Non-Fluorescent DOPC/CHOL Liposomes (300nm)
Synthesis and biological evaluation of selective survivin inhibitors derived from the MX-106 hydroxyquinoline scaffold Albadari, Najah, et al. 2021 European Journal of Medicinal Chemistry … We are currently working with a CRO (Creative BioStructure, Inc) to optimize the crystallization condition in order to obtain the crystal structures of survivin protein in complexes with this … X-ray Crystallography Services
Exosomes of human umbilical cord MSCs protect against hypoxia/reoxygenation-induced pyroptosis of cardiomyocytes via the miRNA-100-5p/FOXO3/NLRP3 pathway Liang, Chenyu, et al. 2021 Frontiers in Bioengineering and Biotechnology … Extracted exosomes were checked using transmission electron microscopy (TEM) (MagHelix, Creative BioStructure, Shirley, NY) … Cryo-EM for Exosome Characterization
All major cholesterol-dependent cytolysins use glycans as cellular receptors Shewell, Lucy K., et al. 2020 Science advances … We thank Creative BioStructure (NY, USA) for protein chemical shift assignment … NMR Spectroscopy Services
Characterization of extracellular vesicles isolated from human milk using a precipitation-based method Bickmore, D.C. and Miklavcic, J.J. 2020 Frontiers in nutrition … Fatty acid analysis was performed by Creative BioStructure (Shirley, NY USA) … Exosome Analysis Services
Quantifying human norovirus virus-like particles binding to commensal bacteria using flow cytometry Madrigal, J.L. and Jones, M.K. 2020 J Vis Exp … VLP Creative BioStructure CBS-V700 human norovirus virus like particle, VLPs were generated using the baculovirus system and resuspended in phosphate buffered saline with 10% … Norovirus GII.3 VLP (VP1 Protein)
Machine learning and big scientific data Hey, Tony, et al. 2020 Philosophical Transactions of the Royal Society A … A schematic of the single-particle reconstruction cryoEM pipeline. Image thanks to Creative BioStructure …  Single Particle Analysis (SPA)
Cryo-EM for small molecules discovery, design, understanding, and application Scapin, G., Potter, C.S. and Carragher, B. 2018 Cell chemical biology … Commercial Options for Cryo-EM Imaging and Supplies … Creative BioStructure …  Cryo-Electron Microscopy (Cryo-EM) Services
Products or services in software, drug discovery or protein production, purification and analysis Biosystems, E. 2010 Nature … Creative BioStructure Services to obtain and analyse crystallographic and NMR structures of macromolecules ... X-ray Crystallography Services, NMR Spectroscopy Services

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