Creative Biostructure to Present at AACR Annual Meeting 2024 | April 5-10, 2024 | Booth #2953 
Microbubble Services
Inquiry
Microbubbles are a new, economically viable, non-invasive alternative to traditional techniques. Microbubbles range in size from 1-100 μm and contain oxygen or air and remain in suspension to prolong drug release. Due to their great potential, microbubbles are used for the delivery of therapeutic drug molecules or genetic material to specific targets in various diseases.
Figure 1. Preparation of micro-bubbles by batch sonication technique. (Sandeep, R., et al., 2021)
Construction of gene-loaded multifunctional polymeric microbubbles
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Construction of ultrasonic microbubble-mediated gene delivery system
- Co-hybrid delivery system. The microbubbles, genes, and cells are in close contact so that the microjets or vibrations generated by microbubble rupture act on the cell membrane surface, enabling rapid gene entry into cells.
- Loaded delivery system. Prepared by physically wrapping the gene drug inside the microbubble or electrostatically adsorbing it to the microbubble surface. The further surface modification allows specific delivery of the microbubble to the target cell, achieving close contact between the microbubble, gene, and cell, and greatly improving the efficiency of gene expression.
- Coupled delivery system. It has sufficient stability for long circulation in the blood to the tumor site and can be targeted by loading ultrasound at specific tissues to achieve local release of the gene carrier.
Technical advantages
- By encapsulating protein drugs in microbubbles for drug delivery, the direct exposure of proteins to the body's immune system can be avoided, reducing the body's immune rejection response and achieving the desired therapeutic effect.
- It increases the permeability of local microvasculature and cell membranes, facilitating the penetration of the drug, thus achieving localized drug release in vivo and improving the therapeutic effect.
Creative Biostructure can prepare microbubbles for your application with great potential. Please contact our staff to learn how we can provide you with solutions related to microbubble drug delivery systems.
Ordering Process
Reference
- Rathor S, et al. A comprehensive review on microbubble concept, development and its application in therapeutic drug delivery and clinical management of disease. Current Pharmaceutical Biotechnology. 2021. 22(11): 1424-1443.
