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Liposome Products
for
Research & Formulation
Explore ready-to-use liposomes, lipids, preparation tools, and lipid nanoparticle products organized around your payload and application.
What Are Liposomes?
Liposomes are spherical vesicles composed of one or more phospholipid bilayers surrounding an aqueous core. This structure allows hydrophilic compounds to be carried in the internal aqueous phase and lipophilic compounds to be incorporated within the lipid bilayer, making liposomes versatile delivery and formulation systems.
Liposome performance is influenced by lipid composition, particle size, lamellarity, surface charge, encapsulated payload, and surface modification. These properties can affect stability, loading efficiency, release behavior, biological interactions, and suitability for pharmaceutical, cosmetic, food, and fundamental research applications.
Creative Biostructure organizes its liposome portfolio by application, encapsulated ingredient or payload, and formulation-related need. Researchers can compare ready-to-use products, formulation components, preparation tools, lipid nanoparticles, and encapsulation kits, or request a custom feasibility review when predefined specifications do not meet the study objective.
Choose Liposome Products by Application
01↗
Research Grade Liposomes
Ready-to-use vesicles and lipid systems for delivery, assay development, membrane studies, and method validation.
Drug
deliveryRNAProteins
02↗
Liposomes for Cosmetics
Active-loaded liposomes designed to support skincare and cosmetic formulation research.
VitaminsPeptidesExtracts
03↗
Liposomes for Food
Food-grade liposomal ingredients for formulation, stability, and bioavailability research.
MineralsVitaminsBioactives
Liposome Formulation Tools & Components
Find the essential products for preparing and developing liposome formulations, including preparation kits, membrane filters, lipids, lipid nanoparticles, and encapsulation kits.
Browse Liposomes by Encapsulated Ingredient
Narrow the catalog by the ingredient or payload you need to encapsulate, from drugs, RNA, and proteins to vitamins, minerals, cosmetic actives, and food ingredients.
Product finder
Search the liposome portfolio
Use a catalog number, product name, or application keyword to search products selected from recent customer inquiries.
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Connected development support
From product selection to
liposome
characterization
The Mempro™ Liposome Platform supports industry and academic teams from manufacturing through analysis. Match an available product to your study or define a custom project with fit-for-purpose characterization.
Explore the Liposome Platform ↗
01
DefinePayload,
application, route
02
FormulateComposition
and preparation
03
CharacterizeSize,
morphology, properties
04
DeliverProduct
and
documentation
Case Study
How lipid headgroups shape liposome mechanics and cellular uptake
An independent Langmuir study combined molecular simulations with DOPC-based formulations to examine how secondary-lipid headgroups influence bilayer stiffness, particle properties, and cell-dependent internalization.
Research question
Can lipid headgroup identity be used to tune DOPC liposome mechanics and uptake?
Liposome mechanics can affect circulation, tissue penetration, and cellular internalization, yet the contribution of lipid headgroup chemistry is not always considered during formulation selection. The researchers asked how five saturated 18-carbon secondary lipids—DSPG, DSPA, DSPS, DSPC, and DSPE—alter DOPC bilayer stiffness and how selected formulations behave in normal epithelial and metastatic breast-cancer cells.
Why this matters for product selection
The study shows that nominal lipid identity alone is not sufficient. Headgroup chemistry, molar ratio, particle size, surface charge, diffusivity, and membrane mechanics can act together to influence biological performance.
Experimental workflow
Multiscale simulation followed by focused in vitro validation
- 01
Model mixed bilayers
All-atom CHARMM36/NAMD and coarse-grained Martini/GROMACS simulations evaluated DOPC with DSPG, DSPA, DSPS, DSPC, or DSPE across multiple molar ratios.
- 02
Calculate molecular interactions
Area compressibility, lipid order, mixing behavior, contacts, and electrostatic potential were assessed; density-functional calculations supported headgroup-level interpretation.
- 03
Prepare selected liposomes
Pure DOPC, DOPC/DSPG, and DOPC/DSPA liposomes were synthesized by solvent injection, with the mixed formulations prepared at 85:15 mol/mol.
- 04
Characterize and test uptake
Dynamic light scattering and zeta-potential measurements were paired with flow-cytometric uptake studies in EpH4-Ev normal epithelial cells and 4T1 metastatic breast-cancer cells.
Key findings
Headgroup chemistry changed stiffness, surface properties, and cell-dependent uptake
| Formulation | Effective diameter | Zeta potential |
|---|---|---|
| L-DOPC | 72 ± 2 nm | +2.4 ± 0.1 mV |
| L-DOPC/DSPG (85:15) | 81 ± 1 nm | −27 ± 1 mV |
| L-DOPC/DSPA (85:15) | 102 ± 3 nm | −36 ± 1 mV |
At a given composition, the simulated stiffness trend was DSPG < DSPA < DSPS < DSPC < DSPE, except at 95:5 where values were statistically similar to pure DOPC. The examined 65:35 systems showed no evidence of phase separation or inhomogeneity.
Study takeaway
Lipid headgroups offer a systematic lever for formulation design
The work supports using secondary-lipid headgroup chemistry and composition to tune DOPC bilayer mechanics. Cellular uptake did not follow stiffness alone: the authors interpreted the results as a combined effect of mechanical properties, negative surface charge, effective diameter, and diffusivity.
Interpretation boundary
The maximum simulated stiffness reduction was modest, and the in vitro comparison covered three selected formulations and two mouse cell lines. The authors call for broader experimental mechanical validation before generalizing performance across payloads, routes, or biological models.
Peer-reviewed source
Full reference
Xu, J.; Adepoju, S.; Pandey, S.; Pérez Tetuán, J.; Williams, M.; Abdelmessih, R. G.; Auguste, D. T.; Hung, F. R. “Effects of Lipid Headgroups on the Mechanical Properties and In Vitro Cellular Internalization of Liposomes.” Langmuir 2025, 41 (4), 2600–2618.
View article via DOIDOI: 10.1021/acs.langmuir.4c04363
Application pathways
Built for diverse research objectives
01
Drug & biologics delivery
Small molecules, oligonucleotides, recombinant proteins, and other research payloads.
02
Cosmetic formulation
Encapsulation of vitamins, peptides, organic acids, botanical extracts, and active complexes.
03
Food formulation
Food-grade liposomal minerals, vitamins, peptides, and bioactive ingredients.
04
Fundamental research
Cell interaction, recognition, membrane behavior, and delivery-mechanism studies.
Frequently asked questions
What to know before selecting a liposome product
Product requirements depend on composition, payload, application, and analytical needs. A short scientific review is the fastest way to identify an available product or define a custom route.
Contact the Creative Biostructure sales team through the online inquiry form. Minimum order quantity varies by product and project requirements; the team will confirm the applicable specification and ordering information.
Our scientists work with defined physical and chemical parameters and can support characterization during manufacturing. Available documentation and testing scope should be confirmed for the selected product or custom project.
Yes. Depending on the project, customization may include vesicle size, lipid composition, encapsulated payload, surface properties, or release profile. Share your target application and acceptance criteria for feasibility review.
Choose an off-the-shelf product when its composition and intended application align with your study. A custom project is more suitable when you need a specific payload, lipid ratio, size distribution, surface modification, or analytical package.
Publications
Published research and scientific context
These peer-reviewed publications provide traceable context for liposome characterization, nanomedicine delivery, and formulation design.
-
01
Sizing Extracellular Vesicles Using Membrane Dyes and a Single Molecule-Sensitive Flow Analyzer
View DOIAndronico, L. A., Jiang, Y., Jung, S.-R., Fujimoto, B. S., Vojtech, L., & Chiu, D. T. (2021). Analytical Chemistry, 93(14), 5897–5905.
The study used Creative Biostructure B-Lipo as defined reference material while developing a membrane-dye workflow for single-vesicle sizing and validating measurements against cryo-EM.
-
02
Nanotechnology for the Efficacious Delivery of Medicinal Cannabis and Pharmaceutical Medicines
View DOIVitetta, L., Henson, J. D., Hayes, E., Rutolo, D., & Hall, S. (2025). Pharmaceuticals, 18(9), 1385.
This review examines nanoparticle-enabled drug delivery—including liposomal approaches—as a strategy to improve targeting and address bioavailability limitations associated with oral administration and first-pass metabolism.
-
03
Effects of Lipid Headgroups on the Mechanical Properties and In Vitro Cellular Internalization of Liposomes
View DOIXu, J., Adepoju, S., Pandey, S., et al. (2025). Langmuir, 41(4), 2600–2618.
Combining molecular simulations with synthesized DOPC-based formulations, the researchers showed that lipid headgroup identity influences membrane mechanics and cell-dependent liposome internalization.
Resources
Brochures and support knowledge
Browse product guides and practical background materials from the existing liposome resource library.
Brochure
Liposome Products for All Imaginable Applications
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Ready-to-use Liposomes for Cosmetics
Brochure
Liposomes for Food
Brochure
Lipid Nanoparticle Products
Support Knowledge
Mempro™ Cationic Liposomes
Support Knowledge
Mempro™ pH-Sensitive Liposomes
Support Knowledge
Mempro™ Immunoliposomes
Support Knowledge
Mempro™ Proteoliposomes
Support Knowledge
