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4. Membrane Protein Expression

Membrane proteins include transmembrane proteins that span across the membrane, Monotypic/peripheral membrane proteins that attached to the lipid bilayer or other integral proteins and peptide. The reason that membrane proteins studies are extremely important is that they are targets of over 50% of all modern drugs. It is estimated that 20-30% of all genes in most genomes encode membrane proteins. However, such proteins are inherently difficult to purify and characterize. The production of membrane protein is an urgent issue to handle with and optimize. Backed by a team with extensive experience in membrane protein production, Creative Biostructure can express and purify membrane proteins that are currently unavailable in the market (e.g., GPCR, ion channels, transporters, enzymes and viral targets).

Following is a list of membrane protein production provided by Creative Biostructure.

Our scientists will assist you in all project stages evaluation, planning and execution. Each project is tailored to the customer’s specifications of scale, purity, analytical characterization and activity. We help our customers plan their projects in the most cost efficient manner. Please feel free to contact us for a detailed quote.

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References

1. Johnson J., Cornell B. (1999). Amphitropic proteins: regulation by reversible membrane interactions. Mol. Membr. Biol. 16: 217-235
2. Overington J., Al-Lazikani B., Hopkins A. (2006). How many drug targets are there? Nat. Rev. Drug. Discov. 5: 993-996

Related Sections

Services:

• Cell-Based Membrane Protein Expression Services
• Cell-free Membrane Protein Expression
• VLP Construction