Subcellular Structure Analysis

As a large, high-resolution instrument, cryogenic electron microscopy (cryo-EM) can be used to study subcellular structures in addition to protein structural analysis. Cryo-electron tomography (cryo-ET) is for subcellular studies, such as the structure of organelles, the distribution of protein molecules, and the composition of cytoskeletons. Extracellular research includes exosomes, biomacromolecules and a series of nano-scale biomaterials. Combined with ultra-low temperature sample manipulation, cryo-EM can provide high-resolution information that connects molecular and cellular level knowledge in order to understand cellular function.

Figure 1. Cellular volume and external features of selected phytoplankton cells revealed by EM imaging. (Uwizeye C, et al. 2021)

In recent years, with the help of the development of computer hardware, the enhancement of data processing ability and the development of electron microscopy, cryo-EM combined with 3D reconstruction has been developed rapidly and made important breakthroughs in the field of structural biology and cell imaging. Cryo-EM can now image subcellular samples including nanomaterials, subcellular organelles, filaments, and biological tissues.

Figure 2. Cryo-EM structures of bacterial nanocompartments shown as radially color-coded, surface-shaded models. (De Ruiter M V, et al. 2019)

If you are interested in our subcellular structure analysis service, please feel free to contact us. We are looking forward to cooperating with you.

Ordering Process

References

1. Uwizeye C, Decelle J, Jouneau P H, et al. Morphological bases of phytoplankton energy management and physiological responses unveiled by 3D subcellular imaging. Nature Communications. 2021, 12(1): 1-12.
2. De Ruiter M V, Klem R, Luque D, et al. Structural nanotechnology: three-dimensional cryo-EM and its use in the development of nanoplatforms for in vitro catalysis. Nanoscale. 2019. 11(10): 4130-4146.