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Product Summary | |
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Name | ARHGEF7 Protein Crystal Download Datasheet |
Background | |
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Background | Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein can induce membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene, but some of their full-length sequences have not been determined. |
Molecular Description | |
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Protein Classification | Signaling Protein |
Structure Weight | 15255.28 Da |
Polymer | 1 |
Molecule | Rho guanine nucleotide exchange factor 7 |
Chain Length | 61 amino acids |
Crystal Description | |
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PDB ID | 2ESW |
MMDB ID | 38672 |
Source | E.coli |
Method | X-Ray Diffraction |
Resolution | 2.01Å |
Ligand Chemical Component | Chloride ion; Mercury ion |
Gene Information | |
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Gene Name | Arhgef7 |
Synonyms | PIX; Cool; Pak3bp; cool-1; p85SPR; betaPix; p85Cool1; betaPix-b; betaPix-c; mKIAA0142; Arhgef7; PAK-interacting exchange factor beta; OTTMUSP00000023238; Pak3 binding protein; Pak interacting exchange factor; Dkfzp761k1021; kiaa0412; p50; p50bp; p85; pak3; pixb |
UniProt ID | Q6XPA5 |
Gene ID | 54126 |
Chromosome Location | 8 A1.1 |
Function | guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity; protein binding |
Reference | |
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Reference | Li, X., Liu, X., Sun, F., Gao, J., Zhou, H., Gao, G.F., Bartlam, M., Rao, Z. (2006) Crystal structure of the N-terminal SH3 domain of mouse betaPIX, p21-activated kinase-interacting exchange factor Biochem. Biophys. Res. Commun. 339: 407-414 |