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Product Summary
Fragment
N-terminal truncated
Protein Description
Neurotrophic Factor Artemin Isoform 3
Background
Artemin (ARTN) is a member of the glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) which regulate the development and maintenance of many neuronal populations in the mammalian nervous system. Here we report the 1.92 A crystal structure of the complex formed between ARTN and its receptor GFRalpha3, which is the initiating step in the formation of a ternary signaling complex containing the shared RET.
Protein Classification
Hormone/growth Factor
Structure Weight
11574.40 Da
PDBID
2GYZ
Method
X-Ray Diffraction
Resolution
1.76Å
Reference
Wang, X., Baloh, R.H., Milbrandt, J., Garcia, K.C. (2006) Structure of Artemin Complexed with Its Receptor GFRalpha3: Convergent Recognition of Glial Cell Line-Derived Neurotrophic Factors. Structure 14: 1083-1092
cDNALength
315