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ARTN Protein Crystal(CBCRY32)

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Product Summary
Name ARTN Protein Crystal Download Datasheet
Background
Background Artemin (ARTN) is a member of the glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) which regulate the development and maintenance of many neuronal populations in the mammalian nervous system. Here we report the 1.92 A crystal structure of the complex formed between ARTN and its receptor GFRalpha3, which is the initiating step in the formation of a ternary signaling complex containing the shared RET.
Molecular Description
Protein ClassificationHormone/growth Factor
Structure Weight11574.40 Da
Polymer1
Moleculeneurotrophic factor artemin isoform 3
Chain Length105 amino acids
Crystal Description
PDB ID2GYZ
MMDB ID40051
SourceE.coli
MethodX-Ray Diffraction
Resolution1.76Å
Gene Information
Gene NameARTN
SynonymsENOVIN; EVN; NBN; OTTHUMP00000009173; OTTHUMP00000009174; neublastin; neurotrophic factor; neurotrophic factor artemin
UniProt IDQ5T4W7
Gene ID9048
Chromosome Location1p33-p32
Functiongrowth factor activity; receptor binding
Reference
Reference Wang, X., Baloh, R.H., Milbrandt, J., Garcia, K.C. (2006) Structure of Artemin Complexed with Its Receptor GFRalpha3: Convergent Recognition of Glial Cell Line-Derived Neurotrophic Factors. Structure 14: 1083-1092

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