Background

Artemin (ARTN) is a member of the glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) which regulate the development and maintenance of many neuronal populations in the mammalian nervous system. Here we report the 1.92 A crystal structure of the complex formed between ARTN and its receptor GFRalpha3, which is the initiating step in the formation of a ternary signaling complex containing the shared RET.

Protein Classification

Hormone/growth Factor

Structure Weight

11574.40 Da

Polymer

1

Molecule

neurotrophic factor artemin isoform 3

Chain Length

105 amino acids

PDB ID

2GYZ

MMDB ID

40051

Source

E.coli

Method

X-Ray Diffraction

Resolution

1.76Å

Gene Name

ARTN

Synonyms

ENOVIN; EVN; NBN; OTTHUMP00000009173; OTTHUMP00000009174; neublastin; neurotrophic factor; neurotrophic factor artemin

UniProt ID

Q5T4W7

Gene ID

9048

Chromosome Location

1p33-p32

Function

growth factor activity; receptor binding

Reference

Wang, X., Baloh, R.H., Milbrandt, J., Garcia, K.C. (2006) Structure of Artemin Complexed with Its Receptor GFRalpha3: Convergent Recognition of Glial Cell Line-Derived Neurotrophic Factors. Structure 14: 1083-1092