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Product Summary
Fragment
Residues 724-1085
Protein Description
Mitotic checkpoint serine/threonine-protein kinase BUB1
Background
The kinase(BUB1) functions in part by phosphorylating a member of the miotic checkpoint complex and activating the spindle checkpoint. Mutations in this gene have been associated with aneuploidy and several forms of cancer.
Protein Classification
Transferase
Structure Weight
42450.29 Da
PDBID
3E7E
Method
X-Ray Diffraction
Resolution
2.31 Å
Ligand Chemical Component
Adenosine-5'-triphosphate; chloride ion; Magnesium ion
Reference
Kang J, Yang M, Li B, Qi W, Zhang C, Shokat KM, Tomchick DR, Machius M, Yu H. Structure and substrate recruitment of the human spindle checkpoint kinase Bub1.Mol Cell. 2008 Nov 7;32(3):394-405.
cDNALength
1095