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CASP3 Protein Crystal(CBCRY39)

Product Summary
Name CASP3 Protein Crystal Download Datasheet
Background
Background Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
Molecular Description
Protein Classificationhydrolase
Structure Weight114694.18 Da
Polymer1
MoleculeCaspase-3
Chain Length253 amino acids
Crystal Description
PDB ID3DEK
MMDB ID66481
SourceE.coli
MethodX-Ray Diffraction
Resolution2.4Å
Ligand Chemical ComponentCysteinesulfonic acid
Gene Information
Gene NameCASP3
SynonymsCPP32; CPP32B; procaspase3; Yama; SCA-1; OTTHUMP00000165054; PARP cleavage protease; SREBP cleavage activity 1; apopain; caspase 3; caspase 3, apoptosis-related cysteine protease; cysteine protease CPP32;
UniProt IDP42574
Gene ID836
Chromosome Location4q34
Functioncysteine-type endopeptidase activity; cyclin-depedent protein kinase inhibitor activity; peptidase activity; cysteine-type peptidase activity; hydrolase activity
Reference
Reference Du, J.-Q., Wu, J., Zhang, H.-J., Zhang, Y.-H., Qiu, B.-Y., Wu, F., Chen, Y.-H., Li, J.-Y., Nan, F.-J., Ding, J.-P., Li, J. (2008) Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species J.Biol.Chem. 283: 30205-30215

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