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CLIC4 Protein Crystal(CBCRY20)

Product Summary
Name CLIC4 Protein Crystal Download Datasheet
Background
Background Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells).
Molecular Description
Protein ClassificationTransport protein
Structure Weight89641.50 Da
Polymer1
MoleculeChloride intracellular channel protein 4
Chain Length261 amino acids
Crystal Description
PDB ID2D2Z
MMDB ID39169
SourceE.coli
MethodX-Ray Diffraction
Resolution2.8Å
Gene Information
Gene NameCLIC4
SynonymsCLIC4L; DKFZp566G223; FLJ38640; H1; MTCLIC; huH1; p64H1; OTTHUMP00000003380; chloride intracellular channel 4 like; Intracellular chloride ion channel protein p64H1
UniProt IDQ9Y696
Gene ID25932
Chromosome Location1p36.11
Functionchloride ion binding; protein binding; voltage-gated chloride channel activity; voltage-gated ion channel activity.
Reference
Reference Li, Y.F., Li, D.F., Zeng, Z.H., Wang, D.C. (2006) Trimeric structure of the wild soluble chloride intracellular ion channel CLIC4 observed in crystals Biochem.Biophys.Res.Commun. 343: 1272-1278

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