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EIF3K Protein Crystal(CBCRY12)

Product Summary
Name EIF3K Protein Crystal Download Datasheet
Background
Background eIF3k, the smallest subunit of eukaryotic initiation factor 3 (eIF3), interacts with several other subunits of eIF3 and the 40 S ribosomal subunit. eIF3k is conserved among high eukaryotes, including mammals, insects, and plants, and it is ubiquitously expressed in human tissues. Interestingly, eIF3k does not exist in some species of yeast. Thus, eIF3k may play a unique regulatory role in higher organisms.
Molecular Description
Protein ClassificationBiosynthetic protein
Structure Weight26532.46 Da
Polymer1
MoleculeEukaryotic translation initiation factor 3 subunit 11
Chain Length250 amino acids
Crystal Description
PDB ID1RZ4
MMDB ID29334
SourceE.coli
MethodX-Ray Diffraction
Resolution2.1 Å
Ligand Chemical Componentsulfate ion
Gene Information
Gene NameEIF3K
SynonymsARG134; EIF3-p28; EIF3S12; HSPC029; M9, MSTP001; PLAC-24,;PLAC24; PRO1474; PTD001; Eukaryotic translation initiation factor 3 subunit 12; Muscle-specific gene M9 protein; eIF-3 p25; eIF-3 p28; eukaryotic translation initiation factor 3, subunit K; muscle specific; ptd001
UniProt IDQ9UBQ5
Gene ID27335
Chromosome Location19q13.2
Functiontranslation initiator factor activity; protein binding; ribosome binding
Reference
Reference Wei, Z., Zhang, P., Zhou, Z., Cheng, Z., Wan, M., Gong, W. (2004) Crystal structure of human eIF3k, the first structure of eIF3 subunits J.Biol.Chem. 279: 34983-34990

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