Background

eIF3k, the smallest subunit of eukaryotic initiation factor 3 (eIF3), interacts with several other subunits of eIF3 and the 40 S ribosomal subunit. eIF3k is conserved among high eukaryotes, including mammals, insects, and plants, and it is ubiquitously expressed in human tissues. Interestingly, eIF3k does not exist in some species of yeast. Thus, eIF3k may play a unique regulatory role in higher organisms.

Protein Classification

Biosynthetic protein

Structure Weight

26532.46 Da

Polymer

1

Molecule

Eukaryotic translation initiation factor 3 subunit 11

Chain Length

250 amino acids

PDB ID

1RZ4

MMDB ID

29334

Source

E.coli

Method

X-Ray Diffraction

Resolution

2.1 Å

Ligand Chemical Component

sulfate ion

Gene Name

EIF3K

Synonyms

ARG134; EIF3-p28; EIF3S12; HSPC029; M9, MSTP001; PLAC-24,;PLAC24; PRO1474; PTD001; Eukaryotic translation initiation factor 3 subunit 12; Muscle-specific gene M9 protein; eIF-3 p25; eIF-3 p28; eukaryotic translation initiation factor 3, subunit K; muscle specific; ptd001

UniProt ID

Q9UBQ5

Gene ID

27335

Chromosome Location

19q13.2

Function

translation initiator factor activity; protein binding; ribosome binding

Reference

Wei, Z., Zhang, P., Zhou, Z., Cheng, Z., Wan, M., Gong, W. (2004) Crystal structure of human eIF3k, the first structure of eIF3 subunits J.Biol.Chem. 279: 34983-34990