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Product Summary
Fragment
Full length
Protein Description
Guanosine monophosphate reductase 2
Background
Guanosine monophosphate reductase (GMPR) Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Plays a role in modulating cellular differentiation.
Protein Classification
Oxidoreductase
Structure Weight
161477.73 Da
PDBID
2A7R
Method
X-Ray Diffraction
Resolution
3.0 Å
Ligand Chemical Component
guanosine-5'-monophosphate; sulfate ion
Reference
Li, J., Wei, Z., Zheng, M., Gu, X., Deng, Y., Qiu, R., Chen, F., Ji, C., Gong, W., Xie, Y., Mao, Y. (2006) Crystal Structure of Human Guanosine Monophosphate Reductase 2 (GMPR2) in Complex with GMP J.Mol.Biol. 355: 980-988
cDNALength
1098