Background

Guanosine monophosphate reductase (GMPR) Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Plays a role in modulating cellular differentiation.

Protein Classification

Oxidoreductase

Structure Weight

161477.73 Da

Polymer

1

Molecule

GMP reductase 2

Chain Length

366 amino acids

PDB ID

2A7R

MMDB ID

37032

Source

E.coli

Method

X-Ray Diffraction

Resolution

3.0 Å

Ligand Chemical Component

guanosine-5'-monophosphate; sulfate ion

Gene Name

GMPR2

Synonyms

MGC15084; MGC830; GMP reductase 2; guanosine 5'-monophosphate oxidoreductase 2; guanosine monophosphate reductase isolog; EC 1.7.1.7

UniProt ID

Q9P2T1

Gene ID

51292

Chromosome Location

14q12

Function

GMP reductase activity; metal ion binding; oxidoreductase activity; potassium ion binding

Reference

Li, J., Wei, Z., Zheng, M., Gu, X., Deng, Y., Qiu, R., Chen, F., Ji, C., Gong, W., Xie, Y., Mao, Y. (2006) Crystal Structure of Human Guanosine Monophosphate Reductase 2 (GMPR2) in Complex with GMP J.Mol.Biol. 355: 980-988