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Product Summary | |
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Name | GPD1 Protein Crystal Download Datasheet |
Background | |
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Background | Homo sapiens L-alpha-glycerol-3-phosphate dehydro-genase 1 (GPD1) catalyzes the reversible biological conversion of dihydroxyacetone (DHAP) to glycerol-3-phosphate. The GPD1 protein was expressed in Escherichia coli, and purified as a fusion protein with glutathione S-transferase. |
Molecular Description | |
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Protein Classification | Oxidoreductase |
Structure Weight | 39164.02 Da |
Polymer | 1 |
Molecule | Glycerol-3-phosphate dehydrogenase {NAD+}, cytoplasmic |
Chain Length | 354 amino acids |
Crystal Description | |
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PDB ID | 1X0X |
MMDB ID | 38469 |
Source | E.coli |
Method | X-Ray Diffraction |
Resolution | 2.75Å |
Ligand Chemical Component | NAD; Sulfate ion |
Gene Information | |
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Gene Name | GPD1 |
Synonyms | FLJ26652; glycerol-3-phosphate dehydro-genase, soluble; glycerol-3-phosphate dehydrogenase 1 (soluble); EC 1.1.1.8; GPD-C; GPDH-C |
UniProt ID | P21695 |
Gene ID | 2819 |
Chromosome Location | 12q12-q13 |
Function | NAD or NADH binding; binding; glycerol-3-phosphate dehydrogense (NAD+) activity; glycerol-3-phosphate dehydrogense activity; protein homodimerization activity |
Reference | |
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Reference | Ou, X., Ji, C., Han, X., Zhao, X., Li, X., Mao, Y., Wong, L.L., Bartlam, M., Rao, Z. (2006) Crystal Structures of Human Glycerol 3-phosphate Dehydrogenase 1 (GPD1) J.Mol.Biol. 357: 858-869 |