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Product Summary
Fragment
Full length
Protein Description
Glycogen Synthase Kinase 3 beta
Background
Glycogen synthase kinase-3 beta is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. It acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1.
Protein Classification
Transferase
Structure Weight
93983.28 Da
PDBID
1I09
Method
X-Ray Diffraction
Resolution
2.70 Å
Ligand Chemical Component
PO4-
Reference
Ter Haar E, Coll JT, Austen DA, Hsiao HM, Swenson L, Jain J. Structure of gsk3beta reveals a primed phosphorylation mechanism. Nat.Struct.Biol. (2001) 8 p.593
cDNALength
1260