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GSK3b Protein Crystal(CBCRY47)

Product Summary
Name GSK3b Protein Crystal Download Datasheet
Background
Background Glycogen synthase kinase-3 beta is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. It acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1.
Molecular Description
Protein ClassificationTransferase
Structure Weight93983.28 Da
Polymer1
MoleculeGLYCOGEN SYNTHASE KINASE-3 BETA
Chain Length420 amino acids
Crystal Description
PDB ID1I09
MMDB ID18277
SourceUnidentified baculovirus
MethodX-Ray Diffraction
Resolution2.70 Å
Ligand Chemical ComponentPO4-
Gene Information
Gene NameGSK3B
SynonymsSerine/threonine-protein kinase GSK3B
UniProt IDP42574
Gene ID2932
Chromosome Location3q13.3
FunctionATP binding; beta-catenin binding; kinase activity; NF-kappaB binding; p53 binding; protein kinase A catalytic subunit binding; protein kinase binding; protein serine/threonine kinase activity; RNA polymerase II transcription factor binding
Reference
Reference Ter Haar E, Coll JT, Austen DA, Hsiao HM, Swenson L, Jain J. Structure of gsk3beta reveals a primed phosphorylation mechanism. Nat.Struct.Biol. (2001) 8 p.593

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