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GSK3b Protein Crystal(CBCRY47)

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Product Summary
Name GSK3b Protein Crystal
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Cat No.CBCRY47
FragmentFull length
Protein DescriptionGlycogen Synthase Kinase 3 beta
BackgroundGlycogen synthase kinase-3 beta is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. It acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1.
Protein ClassificationTransferase
Structure Weight93983.28 Da
MethodX-Ray Diffraction
Resolution2.70 Å
Ligand Chemical ComponentPO4-
ReferenceTer Haar E, Coll JT, Austen DA, Hsiao HM, Swenson L, Jain J. Structure of gsk3beta reveals a primed phosphorylation mechanism. Nat.Struct.Biol. (2001) 8 p.593

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