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IDI1 Protein Crystal(CBCRY10)

Product Summary
Name IDI1 Protein Crystal Download Datasheet
Background
Background IDI1 encodes a peroxisomally-localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP), which are the substrates for the successive reaction that results in the synthesis of farnesyl diphosphate and, ultimately, cholesterol. It has been shown in peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy that there is reduction in IPP isomerase activity.
Molecular Description
Protein ClassificationIsomerase
Structure Weight56107.39 Da
Polymer1
MoleculeIsopentenyl-diphosphate delta-isomerase 1
Chain Length255 amino acids
Crystal Description
PDB ID2I6K
MMDB ID46256
SourceE.coli
MethodX-Ray Diffraction
Resolution2.00 Å
Ligand Chemical ComponentAcetic acid; Aminoethanolpyrophosphate; Magnesium ion; Manganese ion
Gene Information
Gene NameIDI1
SynonymsIPP1; IPPI1; EC 5.5.5.2; IPP isomerase; IPP isomerase; OTTHUMP00000018951; isopentenyl diphosphate dimethylallyl diphosphate isomerase 1; isopentenyl pyrophosphate isomerase 1; isopentenyl-diphosphate delta isomerase
UniProt IDQ13907
Gene ID3422
Chromosome Location10p15.3
Functionmagnesium ion binding; isopentenyl-diphosphate delta-isomerase activity; hydrolase activity; isomerase activity; metal ion binding
Reference
Reference Zhang, C., Liu, L., Xu, H., Wei, Z., Wang, Y., Lin, Y., Gong, W. (2007) Crystal structures of human IPP isomerase: new insights into the catalytic mechanism J.Mol.Biol. 366: 1437-1446

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