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Product Summary
Fragment
Full length
Protein Description
Porphobilinogen deaminase
Background
The protein is the third enzyme of the heme biosynthetic pathway and catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane. Mutations in this gene are associated with the autosomal dominant disease acute intermittent porphyria. Alternatively spliced transcript variants encoding different isoforms have been described.
Protein Classification
Transferase
Structure Weight
80152.23 Da
PDBID
3ECR
Method
X-Ray Diffraction
Resolution
2.18Å
Ligand Chemical Component
DPM
Reference
Song, G., Li, Y., Cheng, C., Zhao, Y., Gao, A., Zhang, R., Joachimiak, A., Shaw, N., Liu, Z.J. (2009) Structural insight into acute intermittent porphyria. Faseb J. 23: 396-404
cDNALength
1092