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Product Summary
Fragment
Catalytic domain
Protein Description
Phosphodiesterase 10
Background
Phosphodiesterase 10A belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate.
Protein Classification
Hydrolase
Structure Weight
76792.17 Da
PDBID
2OUP
Method
X-Ray Diffraction
Resolution
1.56 Å
Ligand Chemical Component
Mg2+ Zn2+
Reference
Wang H, Liu Y, Hou J, Zheng M, Robinson H, Ke H. From the cover: structural insight into substrate specificity of phosphodiesterase 10. Proc.Natl.Acad.Sci.Usa (2007) 104 p.5782
cDNALength
2337