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PDE10A Protein Crystal(CBCRY50)

Product Summary
Name PDE10A Protein Crystal Download Datasheet
Background
Background Phosphodiesterase 10A belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate.
Molecular Description
Protein ClassificationHydrolase
Structure Weight76792.17 Da
Polymer1
MoleculecAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Chain Length331 amino acids
Crystal Description
PDB ID2OUP
MMDB ID45267
SourceE.coli
MethodX-Ray Diffraction
Resolution1.56 Å
Ligand Chemical ComponentMg2+ Zn2+
Gene Information
Gene NamePDE10A
SynonymsHSPDE10A
UniProt IDQ9Y233
Gene ID10846
Chromosome Location6q26
Function3',5'-cyclic-GMP phosphodiesterase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; cAMP binding; cGMP binding; metal ion binding
Reference
Reference Wang H, Liu Y, Hou J, Zheng M, Robinson H, Ke H. From the cover: structural insight into substrate specificity of phosphodiesterase 10. Proc.Natl.Acad.Sci.Usa (2007) 104 p.5782

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