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PLK2 Protein Crystal(CBCRY54)

Product Summary
Name PLK2 Protein Crystal Download Datasheet
Background
Background Polo-like kinase 2 (PLK2) is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. This gene is most abundantly expressed in testis, spleen and fetal tissues, and its expression is inducible by serum, suggesting that it may also play an important role in cells undergoing rapid cell division. Polo-like kinases are the key regulators of cell cycle progression, the members of which share a kinase domain and a polo-box domain that serves as a protein-binding module.
Molecular Description
Protein ClassificationTransferase
Structure Weight50489.28 Da
Polymer1
MoleculeSerine/threonine-protein kinase PLK2
Chain Length218 amino acids
Crystal Description
PDB ID4XB0
MMDB ID129103
SourceE.coli
MethodX-Ray Diffraction
Resolution2.70 Å
Ligand Chemical ComponentPO4-,Cl-
Gene Information
Gene NamePLK2
SynonymsSNK; hSNK; hPlk2
UniProt IDQ9NYY3
Gene ID10769
Chromosome Location5q12.1-q13.2
FunctionATP binding; protein serine/threonine kinase activity; signal transducer activity
Reference
Reference Kim JH, Ku B, Lee KS, Kim SJ. Structural analysis of the polo-box domain of human polo-like kinase 2. Proteins (2015)

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