Background

Pyrroline-5-carboxylate reductase (P5CR) is a universal housekeeping enzyme that catalyzes the reduction of Delta(1)-pyrroline-5-carboxylate (P5C) to proline using NAD(P)H as the cofactor. The enzymatic cycle between P5C and proline is very important for the regulation of amino acid metabolism, intracellular redox potential, and apoptosis.

Protein Classification

Oxidoreductase

Structure Weight

168155.50 Da

Polymer

1

Molecule

Pyrroline-5-carboxylate reductase 1

Chain Length

321 amino acids

PDB ID

2GER

MMDB ID

41542

Source

E.coli

Method

X-Ray Diffraction

Resolution

3.1Å

Gene Name

PYCR1

Synonyms

P5C; P5CR; PIG45; PP222; PYCR; P5C reductase; proliferation-inducing protein 45; pyrroline-5-carboxylate reductase 1; EC 1.5.1.2; P5C reductase 1; P5CR1

UniProt ID

P32322

Gene ID

5831

Chromosome Location

17q25.3

Function

binding; oxidoreductase activity; pyrroline-5-carboxylate resuctase activity

Reference

Meng, Z., Lou, Z., Liu, Z., Li, M., Zhao, X., Bartlam, M., Rao, Z. (2006) Crystal structure of human pyrroline-5-carboxylate reductase J.Mol.Biol. 359: 1364-1377