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PYCR1 Protein Crystal(CBCRY27)

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Product Summary
Name PYCR1 Protein Crystal Download Datasheet
Background
Background Pyrroline-5-carboxylate reductase (P5CR) is a universal housekeeping enzyme that catalyzes the reduction of Delta(1)-pyrroline-5-carboxylate (P5C) to proline using NAD(P)H as the cofactor. The enzymatic cycle between P5C and proline is very important for the regulation of amino acid metabolism, intracellular redox potential, and apoptosis.
Molecular Description
Protein ClassificationOxidoreductase
Structure Weight168155.50 Da
Polymer1
MoleculePyrroline-5-carboxylate reductase 1
Chain Length321 amino acids
Crystal Description
PDB ID2GER
MMDB ID41542
SourceE.coli
MethodX-Ray Diffraction
Resolution3.1Å
Gene Information
Gene NamePYCR1
SynonymsP5C; P5CR; PIG45; PP222; PYCR; P5C reductase; proliferation-inducing protein 45; pyrroline-5-carboxylate reductase 1; EC 1.5.1.2; P5C reductase 1; P5CR1
UniProt IDP32322
Gene ID5831
Chromosome Location17q25.3
Functionbinding; oxidoreductase activity; pyrroline-5-carboxylate resuctase activity
Reference
Reference Meng, Z., Lou, Z., Liu, Z., Li, M., Zhao, X., Bartlam, M., Rao, Z. (2006) Crystal structure of human pyrroline-5-carboxylate reductase J.Mol.Biol. 359: 1364-1377

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