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VPS29 Protein Crystal(CBCRY38)

Product Summary
Name VPS29 Protein Crystal Download Datasheet
Background
Background VPS29 belongs to a group of genes coding for vacuolar protein sorting (VPS) proteins that, when functionally impaired, disrupt the efficient delivery of vacuolar hydrolases. The protein encoded by this gene, Vps29, is a component of a large multimeric complex, termed the retromer complex, which is involved in retrograde transport of proteins from endosomes to the trans-Golgi network. Vps29 may be involved in the formation of the inner shell of the retromer coat for retrograde vesicles leaving the prevacuolar compartment.
Molecular Description
Protein Classificationcytoplasmic protein
Structure Weight20531.90 Da
Polymer1
MoleculeVacuolar Protein Sorting Protein 29
Chain Length182 amino acids
Crystal Description
PDB ID1W24
MMDB ID32322
SourceE.coli
MethodX-Ray Diffraction
Resolution2.10Å
Gene Information
Gene NameVPS29
SynonymsDC15; DC7; DKFZp564F0223; FLJ20492; PEP11; retromer protein; vacuolar protein sorting 29; vacuolar sorting protein VPS29/PEP11; x 007 protein; EC 3.1.3.3; hVPS29; vesicle protein sorting 29
UniProt IDQ9UBQ0
Gene ID51699
Chromosome Location12q24
Functionzinc ion binding; hydrolase activity; metal ion binding
Reference
Reference Wang, D., Guo, M., Liang, Z., Fan, J., Zhu, Z., Zang, J., Zhu, Z., Li, X., Teng, M., Niu, L., Dong, Y., Liu, P. (2005) Crystal Structure of Human Vacuolar Protein Sorting Protein 29 Reveals a Phosphodiesterase/Nuclease-Like Fold and Two Protein-Protein Interaction Sites. J.Biol.Chem. 280: 22962

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