AR, Androgen Receptor

Tel:

Fax:

Email:

Featured Services & Products

Promise

Our promise to you: Guaranteed product quality, expert customer support.

24x7 CUSTOMER SERVICE

CONTACT US TO ORDER

AR Protein Crystal(CBCRY23)

Inquiry

Product Summary
Name	AR Protein Crystal Download Datasheet

Background
Background	Androgen receptor (AR) is a ligand-inducible steroid hormone receptor that mediates androgen action, determining male sexual phenotypes and promoting spermatogenesis. As the androgens play a dominant role in male sexual development and function, steroidal androgen agonists have been used clinically for some years. However, there is a risk of potential side effects and most steroidal androgens cannot be dosed orally, which limits the use of these substances. 1,2-Dihydro-6-N,N-bis(2,2,2-trifluoroethyl)amino-4-trifluoromethyl-2-quinolinone (LGD2226) is a synthetic nonsteroidal ligand and a novel selective AR modulator.

Background

Androgen receptor (AR) is a ligand-inducible steroid hormone receptor that mediates androgen action, determining male sexual phenotypes and promoting spermatogenesis. As the androgens play a dominant role in male sexual development and function, steroidal androgen agonists have been used clinically for some years. However, there is a risk of potential side effects and most steroidal androgens cannot be dosed orally, which limits the use of these substances. 1,2-Dihydro-6-N,N-bis(2,2,2-trifluoroethyl)amino-4-trifluoromethyl-2-quinolinone (LGD2226) is a synthetic nonsteroidal ligand and a novel selective AR modulator.

Molecular Description
Protein Classification	Ligand Binding Protein
Structure Weight	29541.62 Da
Polymer	1
Molecule	Androgen receptor
Chain Length	250 amino acids

Crystal Description
PDB ID	2HVC
MMDB ID	53414
Source	E.coli
Method	X-Ray Diffraction
Resolution	2.8Å
Ligand Chemical Component	6-[Bis(2,2,2-Trifluoroethyl)Amino]-4-(Trifluoromethyl)quinolin-2(1H)-one.

Gene Information
Gene Name	AR
Synonyms	RP11-383C12.1; AIS, DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM; OTTHUMP00000023450; OTTHUMP00000061928; dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4; spinal and bulbar muscular atrophy
UniProt ID	P10275
Gene ID	367
Chromosome Location	Xq11.2-q12
Function	androgen binding; androgen receptor activity; metal ion binding; receptor activity; protein dimerization activity; receptor binding; sequence-specific DNA binding; transcription factor activity; zinc ion binding

Reference
Reference	Wang, F., Liu, X.-Q., Li, H., Liang, K.-N., Miner, J.N., Hong, M., Kallel, E.A., van Oeveren, A., Zhi, L., Jiang, T. (2006) Structure of the ligand-binding domain (LBD) of human androgen receptor in complex with a selective modulator LGD2226 ACTA CRYSTALLOGR.,SECT.F 62: 1067-1071

AR Protein Crystal

Promise

AR Protein Crystal(CBCRY23)

Online Inquiry