BPGM Protein Crystal

Background

Bisphosphoglycerate mutase is an erythrocyte-specific enzyme catalyzing a series of intermolecular phosphoryl group transfer reactions. Its main function is to synthesize 2,3-bisphosphoglycerate, the allosteric effector of hemoglobin.

Protein Classification

Isomerase

Structure Weight

63399.57 Da

Polymer

1

Molecule

Bisphosphoglycerate mutase

Chain Length

271 amino acids

PDB ID

2HHJ

MMDB ID

53343

Source

E.coli

Method

X-Ray Diffraction

Resolution

1.5 Å

Ligand Chemical Component

3-phosphoglyceric acid; 2,3-diphosphoglyceric acid; cyclohexylammonium ion

Gene Name

BPGM

Synonyms

EC 5.4.2.4; EC 5.4.2.1; EC 3.1.3.13; 2,3-bisphosphoglycerate mutase; 2,3-bisphosphoglycerate mutase, erythrocyte; 2,3-bisphosphoglycerate synthase; BPG-dependent PGAM

UniProt ID

P07738

Gene ID

669

Chromosome Location

7q31-q34

Function

bisphosphoglycerate 2-phosphatase activity; bisphosphoglycerate mutase activity; hydrolase activity; isomerase activity; phosphoglycerate mutase activity; intramolecular transferase activity; phosphatrasferase

Reference

Wang, Y., Liu, L., Wei, Z., Cheng, Z., Lin, Y., Gong, W. (2006) Seeing the process of histidine phosphorylation in human bisphosphoglycerate mutase. J.Biol.Chem. 281: 39642-39648