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CRYM Protein Crystal(CBCRY14)

Product Summary
Name CRYM Protein Crystal Download Datasheet
Background Crystallins are separated into two classes: taxon-specific and ubiquitous. The former class is also called phylogenetically-restricted crystallins. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. This gene encodes a taxon-specific crystallin protein that binds NADPH and has sequence similarity to bacterial ornithine cyclodeaminases. The encoded protein does not perform a structural role in lens tissue, and instead it binds thyroid hormone for possible regulatory or developmental roles. Multiple alternatively spliced transcript variants have been found for this gene.
Molecular Description
Protein ClassificationOxidoreductase
Structure Weight68589.65 Da
MoleculeMu-crystallin homolog
Chain Length312 amino acids
Crystal Description
MMDB ID44495
MethodX-Ray Diffraction
Resolution2.6 Å
Ligand Chemical ComponentNAD
Gene Information
Gene NameCRYM
SynonymsDFNA40; THBP; NADP-regulated thyroid-hormone binding protein; OTTHUMP00000115878; dfna40; crystallin mu
UniProt IDQ14894
Gene ID1428
Chromosome Location16p13.11-p12.3
FunctionNADP or NADPH binding; catalytic activity; thyroid hormone binding; transcription corepressor activity
Reference Cheng, Z., Sun, L., He, J., Gong, W. (2007) Crystal structure of human {micro}-crystallin complexed with NADPH Protein Sci. 16: 329-335

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