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Product Summary
Fragment
Full length
Protein Description
Mu-crystallin homolog
Background
Crystallins are separated into two classes: taxon-specific and ubiquitous. The former class is also called phylogenetically-restricted crystallins. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. This gene encodes a taxon-specific crystallin protein that binds NADPH and has sequence similarity to bacterial ornithine cyclodeaminases. The encoded protein does not perform a structural role in lens tissue, and instead it binds thyroid hormone for possible regulatory or developmental roles. Multiple alternatively spliced transcript variants have been found for this gene.
Protein Classification
Oxidoreductase
Structure Weight
68589.65 Da
PDBID
2I99
Method
X-Ray Diffraction
Resolution
2.6 Å
Ligand Chemical Component
NAD
Reference
Cheng, Z., Sun, L., He, J., Gong, W. (2007) Crystal structure of human {micro}-crystallin complexed with NADPH Protein Sci. 16: 329-335
cDNALength
936