Background

The human light chain of the motor protein dynein, Dnlc2A, is also a novel TGF-beta-signaling component, which is altered with high frequency in epithelial ovarian cancer. It is an important mediator of dynein and the development of cancer, owing to its ability to bind to the dynein intermediate light chain (DIC) IC74 and to regulate TGF-beta-dependent transcriptional events.

Protein Classification

Transport Protein

Structure Weight

24324.71 Da

Polymer

1

Molecule

Dynein light chain 2A, cytoplasmic

Chain Length

106 amino acids

PDB ID

2HZ5

MMDB ID

53434

Source

E.coli

Method

X-Ray Diffraction

Resolution

2.10Å

Ligand Chemical Component

Cesium ion

Gene Name

DYNLRB1

Synonyms

BITH; BLP; DNCL2A; DNLC2A; ROBLD1; OTTHUMP00000030691; ROBL/LC7-like 1; Roadblock-1; bithoraxoid-like protein; cytoplasmic dynein light chain 2A; dynein, cytoplasmic, light polypeptide 2A; dynein-associated protein HKM23; dynein-associated protein Km23; roadblock domain containing 1

UniProt ID

Q9NP97

Gene ID

83658

Chromosome Location

20q11.21

Function

microtubule motor activity; protein binding

Reference

Liu, J.-F., Wang, Z.-X., Wang, X.-Q., Tang, Q., An, X.-M., Gui, L.-L., Liang, D.-C. (2006) Crystal structure of human dynein light chain Dnlc2A: Structural insights into the interaction with IC74 Biochem.Biophys.Res.Commun. 349: 1125-1129