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MAD2 with p31 Protein Crystal(CBCRY03)

Product Summary
Name MAD2 with p31 Protein Crystal Download Datasheet
Background The crystal structure of the Mad2-p31(comet) complex is reported. The C-terminal region of Mad2 that undergoes rearrangement in different Mad2 conformers is a major structural determinant for p31(comet) binding, explaining the specificity of p31(comet) toward Mad1- or Cdc20-bound Mad2. p31(comet) adopts a fold strikingly similar to that of Mad2 and binds at the dimerization interface of Mad2. Thus, p31(comet) exploits the two-state behavior of Mad2 to block its activation by acting as an "anti-Mad2."
Molecular Description
Protein Classificationcell cycle
Structure Weight105471.24 Da
MoleculeMitotic spindle assembly checkpoint protein MAD2A
Chain Length210 amino acids
MoleculeMAD2L1-binding protein
Chain Length268 amino acids
Chain Length12 amino acids
Crystal Description
MethodX-Ray Diffraction
Resolution2.30 Å
Gene Information
Gene NameMAD2L1
SynonymsHSMAD2; MAD2; MAD2 (mitotic arrest deficient, yeast, homolog)-like 1; MAD2-like 1; MAD2-like protein 1; mitotic arrest deficient, yeast, homolog-like 1
UniProt IDQ13257
Gene ID4085
Chromosome Location4q27
Functionprotein binding
Gene NameMAD2L1BP
SynonymsMAD2L1 binding protein; CMT2, KIAA0110, MGC11282, RP1-261G23.6; OTTHUMP00000016496; caught by MAD2 protein; KIAA0110; dJ261G23.1
UniProt IDQ15013
Gene ID9587
Chromosome Location6p21.1
Functionprotein binding
Reference Yang, M., Li, B., Tomchick, D.R., Machius, M., Rizo, J., Yu, H., Luo, X. p31comet blocks Mad2 activation through structural mimicry.Cell(Cambridge,Mass.)2007; 131: 744-755

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