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Product Summary | |
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Name | MAD2 with p31 Protein Crystal Download Datasheet |
Background | |
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Background | The crystal structure of the Mad2-p31(comet) complex is reported. The C-terminal region of Mad2 that undergoes rearrangement in different Mad2 conformers is a major structural determinant for p31(comet) binding, explaining the specificity of p31(comet) toward Mad1- or Cdc20-bound Mad2. p31(comet) adopts a fold strikingly similar to that of Mad2 and binds at the dimerization interface of Mad2. Thus, p31(comet) exploits the two-state behavior of Mad2 to block its activation by acting as an "anti-Mad2." |
Molecular Description | |
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Protein Classification | cell cycle |
Structure Weight | 105471.24 Da |
Polymer | 1 |
Molecule | Mitotic spindle assembly checkpoint protein MAD2A |
Chain Length | 210 amino acids |
Polymer | 2 |
Molecule | MAD2L1-binding protein |
Chain Length | 268 amino acids |
Polymer | 3 |
Molecule | peptide |
Chain Length | 12 amino acids |
Crystal Description | |
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PDB ID | 2QYF |
Source | E.coli |
Method | X-Ray Diffraction |
Resolution | 2.30 Å |
Gene Information | |
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Gene Name | MAD2L1 |
Synonyms | HSMAD2; MAD2; MAD2 (mitotic arrest deficient, yeast, homolog)-like 1; MAD2-like 1; MAD2-like protein 1; mitotic arrest deficient, yeast, homolog-like 1 |
UniProt ID | Q13257 |
Gene ID | 4085 |
Chromosome Location | 4q27 |
Function | protein binding |
Gene Name | MAD2L1BP |
Synonyms | MAD2L1 binding protein; CMT2, KIAA0110, MGC11282, RP1-261G23.6; OTTHUMP00000016496; caught by MAD2 protein; KIAA0110; dJ261G23.1 |
UniProt ID | Q15013 |
Gene ID | 9587 |
Chromosome Location | 6p21.1 |
Function | protein binding |
Reference | |
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Reference | Yang, M., Li, B., Tomchick, D.R., Machius, M., Rizo, J., Yu, H., Luo, X. p31comet blocks Mad2 activation through structural mimicry.Cell(Cambridge,Mass.)2007; 131: 744-755 |