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PLK1 Protein Crystal(CBCRY53)

Product Summary
Name PLK1 Protein Crystal Download Datasheet
Background Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. The Ser/Thr protein kinase belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of this protein in cancer cells dramatically inhibited cell proliferation and induced apoptosis; hence, it is a target for cancer therapy.
Molecular Description
Protein ClassificationTransferase
Structure Weight54544.60 Da
MoleculeSerine/threonine-protein kinase PLK
Chain Length237 amino acids
Crystal Description
MMDB ID25396
MethodX-Ray Diffraction
Resolution2.20 Å
Gene Information
Gene NamePLK1
SynonymsPLK; STPK13
UniProt IDP53350
Gene ID5347
Chromosome Location16p12.2
Functionanaphase-promoting complex binding; ATP binding; kinase activity; microtubule binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity
Reference Cheng KY, Lowe ED, Sinclair J, Nigg EA, Johnson LN. The crystal structure of the human polo-like kinase-1 polo box domain and its phospho-peptide complex. Embo J. (2003) 22 p.5757

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