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PLK4 Protein Crystal(CBCRY56)

Product Summary
Name PLK4 Protein Crystal Download Datasheet
Background
Background Polo-like kinase 4 (PLK4) belongs to the polo family of serine/threonine protein kinases. PLK4 localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. PLK4 is involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1.
Molecular Description
Protein ClassificationTransferase
Structure Weight64844.43 Da
Polymer1
MoleculeSerine/threonine-protein kinase PLK4
Chain Length278 amino acids
Crystal Description
PDB ID3COK
MMDB ID63866
SourceE.coli
MethodX-Ray Diffraction
Resolution2.25 Å
Ligand Chemical ComponentSULFATE ION, ANP
Gene Information
Gene NamePLK4
SynonymsSAK; STK18; MCCRP2
UniProt IDO00444
Gene ID10733
Chromosome Location4q28
FunctionATP binding; protein serine/threonine kinase activity
Reference
Reference Atwell S, Burley SK, Houle A, Leon B, Pelletier LA, Sauder JM. Crystal structure of plk4 kinase. No recorded citation in PubMed.

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