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Product Summary
Fragment
Polo box domain
Protein Description
Polo-like Kinase 4
Background
Polo-like kinase 4 (PLK4) belongs to the polo family of serine/threonine protein kinases. PLK4 localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. PLK4 is involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1.
Protein Classification
Transferase
Structure Weight
64844.43 Da
PDBID
3COK
Method
X-Ray Diffraction
Resolution
2.25 Å
Ligand Chemical Component
SULFATE ION, ANP
Reference
Atwell S, Burley SK, Houle A, Leon B, Pelletier LA, Sauder JM. Crystal structure of plk4 kinase. No recorded citation in PubMed.
cDNALength
2910