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PPARG Protein Crystal(CBCRY34)

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Product Summary
Name	PPARG Protein Crystal Download Datasheet

Background
Background	PPARG regulates fatty acid storage and glucose metabolism. Many insulin sensitizing drugs used in the treatment of diabetes target PPARG as a means to lower serum glucose without increasing pancreatic insulin secretion. The genes activated by PPARG stimulate lipid uptake and adipogenesis by fat cells. PPARG knockout mice fail to generate adipose tissue when fed a high fat diet.

Molecular Description
Protein Classification	transcription
Structure Weight	34246.95 Da
Polymer	1
Molecule	Peroxisome proliferator-activated receptor gamma
Chain Length	296 amino acids

Crystal Description
PDB ID	3BC5
MMDB ID	67970
Source	E.coli
Method	X-Ray Diffraction
Resolution	2.27Å
Ligand Chemical Component	ZAA

Gene Information
Gene Name	PPARG
Synonyms	CIMT1; NR1C3; PPARG1; PPARG2; PPAR-gamma; HUMPPARG; OTTHUMP00000185030; OTTHUMP00000185033; OTTHUMP00000185037; PPAR gamma; nuclear receptor subfamily 1 group C member 3; peroxisome proliferative activated receptor gamma; peroxisome proliferator-activated receptor gamma 1; nuclear receptor subfamily 1 group C member 3
UniProt ID	P37231
Gene ID	5468
Chromosome Location	3p25
Function	arachidonic acid binding; drug binding; metal ion binding; prostaglandin receptor activity; protein heterodimerization activity; retinoid X receptor binding; steroid hormone receptor activity; zinc ion binding

Reference
Reference	Zhang, H., Ryono, D.E., Devasthale, P., Wang, W., O`Malley, K., Farrelly, D., Gu, L., Harrity, T., Cap, M., Chu, C., Locke, K., Zhang, L., Lippy, J., Kunselman, L., Morgan, N., Flynn, N., Moore, L., Hosagrahara, V., Zhang, L., Kadiyala, P., Xu, C., Doweyko, A.M., Bell, A., Chang, C., Muckelbauer, J., Zahler, R., Hariharan, N., Cheng, P.T. (2009) Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists. Bioorg

Reference

Zhang, H., Ryono, D.E., Devasthale, P., Wang, W., O`Malley, K., Farrelly, D., Gu, L., Harrity, T., Cap, M., Chu, C., Locke, K., Zhang, L., Lippy, J., Kunselman, L., Morgan, N., Flynn, N., Moore, L., Hosagrahara, V., Zhang, L., Kadiyala, P., Xu, C., Doweyko, A.M., Bell, A., Chang, C., Muckelbauer, J., Zahler, R., Hariharan, N., Cheng, P.T. (2009) Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists. Bioorg

PPARG Protein Crystal

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PPARG Protein Crystal(CBCRY34)

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