PPARG regulates fatty acid storage and glucose metabolism. Many insulin sensitizing drugs used in the treatment of diabetes target PPARG as a means to lower serum glucose without increasing pancreatic insulin secretion. The genes activated by PPARG stimulate lipid uptake and adipogenesis by fat cells. PPARG knockout mice fail to generate adipose tissue when fed a high fat diet.
Molecular Description
Protein Classification
transcription
Structure Weight
34246.95 Da
Polymer
1
Molecule
Peroxisome proliferator-activated receptor gamma
Chain Length
296 amino acids
Crystal Description
PDB ID
3BC5
MMDB ID
67970
Source
E.coli
Method
X-Ray Diffraction
Resolution
2.27Å
Ligand Chemical Component
ZAA
Gene Information
Gene Name
PPARG
Synonyms
CIMT1; NR1C3; PPARG1; PPARG2; PPAR-gamma; HUMPPARG; OTTHUMP00000185030; OTTHUMP00000185033; OTTHUMP00000185037; PPAR gamma; nuclear receptor subfamily 1 group C member 3; peroxisome proliferative activated receptor gamma; peroxisome proliferator-activated receptor gamma 1; nuclear receptor subfamily 1 group C member 3
UniProt ID
P37231
Gene ID
5468
Chromosome Location
3p25
Function
arachidonic acid binding; drug binding; metal ion binding; prostaglandin receptor activity; protein heterodimerization activity; retinoid X receptor binding; steroid hormone receptor activity; zinc ion binding
Reference
Reference
Zhang, H., Ryono, D.E., Devasthale, P., Wang, W., O`Malley, K., Farrelly, D., Gu, L., Harrity, T., Cap, M., Chu, C., Locke, K., Zhang, L., Lippy, J., Kunselman, L., Morgan, N., Flynn, N., Moore, L., Hosagrahara, V., Zhang, L., Kadiyala, P., Xu, C., Doweyko, A.M., Bell, A., Chang, C., Muckelbauer, J., Zahler, R., Hariharan, N., Cheng, P.T. (2009) Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists. Bioorg
Download Datasheet 