Background

MAD2 (mitotic arrest deficient 2) is one of the kinetochore protein present on the chromosome during cell division. It is involved in making sure all chromosomes are attached to the mitotic spindle before the beginning of anaphase.

Protein Classification

Cell Cycle

Structure Weight

288687.00 Da

Polymer

1

Molecule

Mitotic Spindle assembly checkpoint protein MAD2A

Chain Length

206 amino acids

PDB ID

2VFX

MMDB ID

63130

Source

E.coli

Method

X-Ray Diffraction

Resolution

1.95 Å

Ligand Chemical Component

Chloride ion, Magnesium ion, PE3, PE4, PEG

Gene Name

MAD2L1

Synonyms

HSMAD2; MAD2; MAD2 (mitotic arrest deficient, yeast, homolog)-like 1; MAD2-like 1; MAD2-like protein 1; mitotic arrest deficient, yeast, homolog-like 1

UniProt ID

Q13257

Gene ID

4085

Chromosome Location

4q27

Function

protein binding

Reference

Yang, M., Li, B., Liu, C.-J., Tomchick, D.R., Machius, M., Rizo, J., Yu, H., Luo, X. (2008) Insights Into MAD2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric MAD2 Dimer. Plos Biol. 6: E50