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Product Summary | |
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Name | MARK2 Protein Crystal Download Datasheet |
Background | |
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Background | This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. It plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. |
Molecular Description | |
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Protein Classification | Signaling Protein/toxin |
Structure Weight | 201373.21 Da |
Polymer | 1 |
Molecule | Serine/threonine-protein kinase MARK2 |
Chain Length | 319 amino acids |
Crystal Description | |
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PDB ID | 3IEC |
MMDB ID | 78596 |
Source | E.coli |
Method | X-Ray Diffraction |
Resolution | 2.20 Å |
Gene Information | |
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Gene Name | MARK2 |
Synonyms | EMK1 |
UniProt ID | Q7KZI7 |
Gene ID | 2011 |
Chromosome Location | 11q13.1 |
Function | ATP binding; lipid binding; magnesium ion binding; poly(A) RNA binding; protein kinase activator activity; protein serine/threonine kinase activity; tau-protein kinase activity |
Reference | |
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Reference | Nesic D, Miller MC, Quinkert ZT, Stein M, Chait BT, Stebbins CE. Helicobacter pylori caga inhibits par1-mark family kinases by mimicking host substrates. Nat.Struct.Mol.Biol. (2010) 17 p.130 |