This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. It plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly.
Molecular Description
Protein Classification
Signaling Protein/toxin
Structure Weight
201373.21 Da
Polymer
1
Molecule
Serine/threonine-protein kinase MARK2
Chain Length
319 amino acids
Crystal Description
PDB ID
3IEC
MMDB ID
78596
Source
E.coli
Method
X-Ray Diffraction
Resolution
2.20 Å
Gene Information
Gene Name
MARK2
Synonyms
EMK1
UniProt ID
Q7KZI7
Gene ID
2011
Chromosome Location
11q13.1
Function
ATP binding; lipid binding; magnesium ion binding; poly(A) RNA binding; protein kinase activator activity; protein serine/threonine kinase activity; tau-protein kinase activity
Reference
Reference
Nesic D, Miller MC, Quinkert ZT, Stein M, Chait BT, Stebbins CE. Helicobacter pylori caga inhibits par1-mark family kinases by mimicking host substrates. Nat.Struct.Mol.Biol. (2010) 17 p.130
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