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MARK2 Protein Crystal(CBCRY41)

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Product Summary
Name MARK2 Protein Crystal Download Datasheet
Background
Background This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. It plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly.
Molecular Description
Protein ClassificationSignaling Protein/toxin
Structure Weight201373.21 Da
Polymer1
MoleculeSerine/threonine-protein kinase MARK2
Chain Length319 amino acids
Crystal Description
PDB ID3IEC
MMDB ID78596
SourceE.coli
MethodX-Ray Diffraction
Resolution2.20 Å
Gene Information
Gene NameMARK2
SynonymsEMK1
UniProt IDQ7KZI7
Gene ID2011
Chromosome Location11q13.1
FunctionATP binding; lipid binding; magnesium ion binding; poly(A) RNA binding; protein kinase activator activity; protein serine/threonine kinase activity; tau-protein kinase activity
Reference
Reference Nesic D, Miller MC, Quinkert ZT, Stein M, Chait BT, Stebbins CE. Helicobacter pylori caga inhibits par1-mark family kinases by mimicking host substrates. Nat.Struct.Mol.Biol. (2010) 17 p.130

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