SAT1 Protein Crystal

Background

Spermidine/spermine N(1)-acetyltransferase (SSAT; EC 2.3.1.57) is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the N(1)-acetylation of spermidine and spermine and, by the successive activity of polyamine oxidase, spermine can be converted to spermidine and spermidine to putrescine.

Protein Classification

Transferase

Structure Weight

42238.60 Da

Polymer

1

Molecule

Diamine acetyltransferase 1

Chain Length

179 amino acids

PDB ID

2G3T

MMDB ID

38382

Source

E.coli

Method

X-Ray Diffraction

Resolution

1.8Å

Gene Name

SAT1

Synonyms

DC21; EC 2.3.1.57; KFSD; SAT; SSAT; SSAT-1;OTTHUMP00000023061; diamine N-acetyltransferase 1; diamine acetyltransferase 1; spermidine/spermine N1-acetyltransferase alpha; spermidine/spermine N1-acetyltransferase 1; Polyamine N-acetyltransferase 1; Putrescine acetyltransferase

UniProt ID

P21673

Gene ID

6303

Chromosome Location

Xp22.1

Function

acyltransferase activity; diamine N-acetyltransferase activity; transferase activity

Reference

Zhu, Y.Q., Zhu, D.Y., Yin, L., Zhang, Y., Vonrhein, C., Wang, D.C. (2006) Crystal structure of human spermidine/spermine N1-acetyltransferase (hSSAT): the first structure of a new sequence family of transferase homologous superfamily Proteins 63: 1127-1131