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SET7/9 Protein Crystal(CBCRY57)

Product Summary
Name SET7/9 Protein Crystal Download Datasheet
Background
Background Histone-lysine N-methyltransferase SETD7 belongs to histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. It plays a central role in the transcriptional activation of genes such as collagenase or insulin. It can be recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. SETD7 has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
Molecular Description
Protein ClassificationTransferase
Structure Weight33421.14 Da
Polymer1
MoleculeSET domain-containing protein 7
Chain Length297 amino acids
Crystal Description
PDB ID1N6C
MMDB ID21841
SourceE.coli
MethodX-Ray Diffraction
Resolution2.30 Å
Ligand Chemical ComponentS-ADENOSYLMETHIONINE
Gene Information
Gene NameSETD7
SynonymsKMT7; SET7; SET9; SET7/9
UniProt IDQ8WTS6
Gene ID80854
Chromosome Location4q28
Functionchromatin binding; histone-lysine N-methyltransferase activity; p53 binding; protein-lysine N-methyltransferase activity
Reference
Reference Kwon T, Chang JH, Kwak E, Lee CW, Joachimiak A, Kim YC, Lee J, Cho Y. Mechanism of histone lysine methyl transfer revealed by the structure of set7/9-adomet. Embo J. (2003) 22 p.292

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