Background

Histone-lysine N-methyltransferase SETD7 belongs to histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. It plays a central role in the transcriptional activation of genes such as collagenase or insulin. It can be recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. SETD7 has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.

Protein Classification

Transferase

Structure Weight

33421.14 Da

Polymer

1

Molecule

SET domain-containing protein 7

Chain Length

297 amino acids

PDB ID

1N6C

MMDB ID

21841

Source

E.coli

Method

X-Ray Diffraction

Resolution

2.30 Å

Ligand Chemical Component

S-ADENOSYLMETHIONINE

Gene Name

SETD7

Synonyms

KMT7; SET7; SET9; SET7/9

UniProt ID

Q8WTS6

Gene ID

80854

Chromosome Location

4q28

Function

chromatin binding; histone-lysine N-methyltransferase activity; p53 binding; protein-lysine N-methyltransferase activity

Reference

Kwon T, Chang JH, Kwak E, Lee CW, Joachimiak A, Kim YC, Lee J, Cho Y. Mechanism of histone lysine methyl transfer revealed by the structure of set7/9-adomet. Embo J. (2003) 22 p.292