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WDR5 Protein Crystal(CBCRY09)

Product Summary
Name WDR5 Protein Crystal Download Datasheet
Background The WD40 repeat protein WDR5 specifically associates with the K4-methylated histone H3 in human cells. The structure of WDR5 in complex with a dimethylated H3-K4 peptide was deterimined. Unlike the chromodomain that recognizes the methylated H3-K4 through a hydrophobic cage, the specificity of WDR5 for methylated H3-K4 is conferred by the nonconventional hydrogen bonds between the two zeta-methyl groups of the dimethylated Lys4 and the carboxylate oxygen of Glu322 in WDR5. The three amino acids Ala-Arg-Thr preceding Lys4 form most of the specific contacts with WDR5, with Ala1 forming intermolecular hydrogen bonds and salt bridges, and the side chain of Arg2 inserting into the central channel of WDR5.
Molecular Description
Protein ClassificationStructural protein and DNA binding protein
Structure Weight35306.44 Da
MoleculeWD-repeat protein 5
Chain Length311 amino acids
MoleculeHistone H3
Chain Length18 amino acids
Crystal Description
MMDB ID41532
MethodX-Ray Diffraction
Resolution2.7 Å
Gene Information
Gene NameWDR5
SynonymsBIG-3; BIG3; BMP2-induced 3-kb gene protein; SWD3, Set1c WD40 repeat protein, homolog; WD-repeat protein 5; WD repeat domain 5
UniProt IDP61964
Gene ID11091
Chromosome Location9q34
Functionprotein binding
Reference Han Z, Guo L, Wang H, Shen Y, Deng XW, Chai J. Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5. Mol. Cell 2006, 22(1):137-44.

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