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FCAR Protein Crystal(CBCRY06)

Product Summary
Name FCAR Protein Crystal Download Datasheet
Background
Background Human FcalphaRI (CD89) is the receptor specific for IgA, an immunoglobulin that is abundant in mucosa and is also found in high concentrations in serum. Although FcalphaRI is an immunoglobulin Fc receptor (FcR), it differs in many ways from FcRs for other immunoglobulin classes. The genes of most FcRs are located on chromosome 1 at 1q21-23, whereas FcalphaRI is on chromosome 19, at 19q13.4, a region called the leukocyte receptor complex, because it is clustered with several leukocyte receptor families including killer cell inhibitory receptors (KIRs) and leukocyte Ig-like receptors (LIRs). The amino acid sequence of FcalphaRI shares only 20% homology with other FcRs but it has around 35% homology with its neighboring LIRs and KIRs.
Molecular Description
Protein ClassificationImmune System
Structure Weight25006.40 Da
Polymer1
MoleculeImmunoglobulin alpha Fc receptor
Chain Length218 amino acids
Crystal Description
PDB ID1UCT
MMDB ID24338
SourceE.coli
MethodX-Ray Diffraction
Resolution2.1 Å
Gene Information
Gene NameFCAR
SynonymsXXbac-BPG230H20.5, CD89; Fc alpha receptor; IgA Fc receptor; OTTHUMP00000068692; OTTHUMP00000068696; OTTHUMP00000068697; OTTHUMP00000068698; CD89; CD89 antigen; Fc receptor; Fc fragment of IgA, receptor; IgA Fc receptor
UniProt IDP24071
Gene ID2204
Chromosome Location19q13.2-q13.4
FunctionIgA binding; receptor activity
Reference
Reference Ding, Y., Xu, G., Yang, M., Yao, M., Gao, G.F., Zhang, W., Rao, Z. Crystal Structure of the Ectodomain of Human Fc{alpha}RI.J.Biol.Chem. 2003; 278: 27966-27970

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