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Product Summary
Fragment
Residues 0-217
Protein Description
Extracellular fragment of Fc alpha Receptor I (CD89)
Background
Human FcalphaRI (CD89) is the receptor specific for IgA, an immunoglobulin that is abundant in mucosa and is also found in high concentrations in serum. Although FcalphaRI is an immunoglobulin Fc receptor (FcR), it differs in many ways from FcRs for other immunoglobulin classes. The genes of most FcRs are located on chromosome 1 at 1q21-23, whereas FcalphaRI is on chromosome 19, at 19q13.4, a region called the leukocyte receptor complex, because it is clustered with several leukocyte receptor families including killer cell inhibitory receptors (KIRs) and leukocyte Ig-like receptors (LIRs). The amino acid sequence of FcalphaRI shares only 20% homology with other FcRs but it has around 35% homology with its neighboring LIRs and KIRs.
Protein Classification
Immune System
Structure Weight
25006.40 Da
PDBID
1UCT
Method
X-Ray Diffraction
Resolution
2.1 Å
Reference
Ding, Y., Xu, G., Yang, M., Yao, M., Gao, G.F., Zhang, W., Rao, Z. Crystal Structure of the Ectodomain of Human Fc{alpha}RI.J.Biol.Chem. 2003; 278: 27966-27970
cDNALength
651