Background

The protein encoded by MARK3 is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Microtubule affinity-regulating kinase 3 phosphorylates CDC25C on 'Ser-216'. It regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus.

Protein Classification

Transferase

Structure Weight

75337.80 Da

Polymer

1

Molecule

MAP/microtubule affinity-regulating kinase 3

Chain Length

328 amino acids

PDB ID

2QNJ

MMDB ID

59510

Source

E.coli

Method

X-Ray Diffraction

Resolution

2.70 Å

Gene Name

MARK3

Synonyms

CTAK1, EMK2

UniProt ID

P27448

Gene ID

4140

Chromosome Location

14q32.32

Function

ATP binding; protein serine/threonine kinase activity

Reference

Murphy, J.M., Korzhnev, D.M., Ceccarelli, D.F., Briant, D.J., Zarrine-Afsar, A., Sicheri, F., Kay, L.E., Pawson, T. Conformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domain. (2007) Proc.Natl.Acad.Sci.Usa 104: 14336-14341