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MARK3 Protein Crystal(CBCRY42)

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Product Summary
Name MARK3 Protein Crystal Download Datasheet
Background
Background The protein encoded by MARK3 is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Microtubule affinity-regulating kinase 3 phosphorylates CDC25C on 'Ser-216'. It regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus.
Molecular Description
Protein ClassificationTransferase
Structure Weight75337.80 Da
Polymer1
MoleculeMAP/microtubule affinity-regulating kinase 3
Chain Length328 amino acids
Crystal Description
PDB ID2QNJ
MMDB ID59510
SourceE.coli
MethodX-Ray Diffraction
Resolution2.70 Å
Gene Information
Gene NameMARK3
SynonymsCTAK1, EMK2
UniProt IDP27448
Gene ID4140
Chromosome Location14q32.32
FunctionATP binding; protein serine/threonine kinase activity
Reference
Reference Murphy, J.M., Korzhnev, D.M., Ceccarelli, D.F., Briant, D.J., Zarrine-Afsar, A., Sicheri, F., Kay, L.E., Pawson, T. Conformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domain. (2007) Proc.Natl.Acad.Sci.Usa 104: 14336-14341

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