The protein encoded by MARK3 is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Microtubule affinity-regulating kinase 3 phosphorylates CDC25C on 'Ser-216'. It regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus.
Molecular Description
Protein Classification
Transferase
Structure Weight
75337.80 Da
Polymer
1
Molecule
MAP/microtubule affinity-regulating kinase 3
Chain Length
328 amino acids
Crystal Description
PDB ID
2QNJ
MMDB ID
59510
Source
E.coli
Method
X-Ray Diffraction
Resolution
2.70 Å
Gene Information
Gene Name
MARK3
Synonyms
CTAK1, EMK2
UniProt ID
P27448
Gene ID
4140
Chromosome Location
14q32.32
Function
ATP binding; protein serine/threonine kinase activity
Reference
Reference
Murphy, J.M., Korzhnev, D.M., Ceccarelli, D.F., Briant, D.J., Zarrine-Afsar, A., Sicheri, F., Kay, L.E., Pawson, T. Conformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domain. (2007) Proc.Natl.Acad.Sci.Usa 104: 14336-14341