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Product Summary
Fragment
Polo box domain
Protein Description
Polo-like Kinase 3
Background
Polo-like kinase 3 (PLK3) is a member of the highly conserved polo-like kinase family of serine/threonine kinases that are critical regulators of cell cycle progression, mitosis, cytokinesis, and the DNA damage response. Members of this family are characterized by an amino-terminal kinase domain and a carboxy-terminal bipartite polo box domain that functions as a substrate-binding motif and a cellular localization signal. This gene has also been implicated in stress responses and double-strand break repair. In human cell lines, this protein is reported to associate with centrosomes in a microtubule-dependent manner, and during mitosis, the protein becomes localized to the mitotic apparatus.
Protein Classification
Transferase
Structure Weight
32791.14 Da
PDBID
4B6L
Method
X-Ray Diffraction
Resolution
1.90 Å
Ligand Chemical Component
SULFATE ION, 9ZP
Reference
Brown K, Charrier JD, Durrant S, Griffiths M, Hudson C, Kay D, Knegtel R, Odonnell M, Pierard F, Twin H, Weber P, Young S. Discovery of oral polo-like kinase (Plk) inhibitors with enhanced selectivity profile using residue targeted drug design. No recorded citation in PubMed
cDNALength
1938