Our promise to you: Guaranteed product quality, expert customer support.
24x7 CUSTOMER SERVICE
CONTACT US TO ORDER
Product Summary | |
---|---|
Name | PLK3 Protein Crystal Download Datasheet |
Background | |
---|---|
Background | Polo-like kinase 3 (PLK3) is a member of the highly conserved polo-like kinase family of serine/threonine kinases that are critical regulators of cell cycle progression, mitosis, cytokinesis, and the DNA damage response. Members of this family are characterized by an amino-terminal kinase domain and a carboxy-terminal bipartite polo box domain that functions as a substrate-binding motif and a cellular localization signal. This gene has also been implicated in stress responses and double-strand break repair. In human cell lines, this protein is reported to associate with centrosomes in a microtubule-dependent manner, and during mitosis, the protein becomes localized to the mitotic apparatus. |
Molecular Description | |
---|---|
Protein Classification | Transferase |
Structure Weight | 32791.14 Da |
Polymer | 1 |
Molecule | SERINE/THREONINE-PROTEIN KINASE PLK3 |
Chain Length | 281 amino acids |
Crystal Description | |
---|---|
PDB ID | 4B6L |
MMDB ID | 112743 |
Source | Spodoptera frugiperda |
Method | X-Ray Diffraction |
Resolution | 1.90 Å |
Ligand Chemical Component | SULFATE ION, 9ZP |
Gene Information | |
---|---|
Gene Name | PLK3 |
Synonyms | CNK; FNK; PRK; PLK-3 |
UniProt ID | Q9H4B4 |
Gene ID | 1263 |
Chromosome Location | 1p34.1 |
Function | ATP binding; p53 binding; protein serine/threonine kinase activity |
Reference | |
---|---|
Reference | Brown K, Charrier JD, Durrant S, Griffiths M, Hudson C, Kay D, Knegtel R, Odonnell M, Pierard F, Twin H, Weber P, Young S. Discovery of oral polo-like kinase (Plk) inhibitors with enhanced selectivity profile using residue targeted drug design. No recorded citation in PubMed |