Polo-like kinase 3 (PLK3) is a member of the highly conserved polo-like kinase family of serine/threonine kinases that are critical regulators of cell cycle progression, mitosis, cytokinesis, and the DNA damage response. Members of this family are characterized by an amino-terminal kinase domain and a carboxy-terminal bipartite polo box domain that functions as a substrate-binding motif and a cellular localization signal. This gene has also been implicated in stress responses and double-strand break repair. In human cell lines, this protein is reported to associate with centrosomes in a microtubule-dependent manner, and during mitosis, the protein becomes localized to the mitotic apparatus.
Molecular Description
Protein Classification
Transferase
Structure Weight
32791.14 Da
Polymer
1
Molecule
SERINE/THREONINE-PROTEIN KINASE PLK3
Chain Length
281 amino acids
Crystal Description
PDB ID
4B6L
MMDB ID
112743
Source
Spodoptera frugiperda
Method
X-Ray Diffraction
Resolution
1.90 Å
Ligand Chemical Component
SULFATE ION, 9ZP
Gene Information
Gene Name
PLK3
Synonyms
CNK; FNK; PRK; PLK-3
UniProt ID
Q9H4B4
Gene ID
1263
Chromosome Location
1p34.1
Function
ATP binding; p53 binding; protein serine/threonine kinase activity
Reference
Reference
Brown K, Charrier JD, Durrant S, Griffiths M, Hudson C, Kay D, Knegtel R, Odonnell M, Pierard F, Twin H, Weber P, Young S. Discovery of oral polo-like kinase (Plk) inhibitors with enhanced selectivity profile using residue targeted drug design. No recorded citation in PubMed
Download Datasheet 