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PLK3 Protein Crystal(CBCRY55)

Product Summary
Name PLK3 Protein Crystal Download Datasheet
Background
Background Polo-like kinase 3 (PLK3) is a member of the highly conserved polo-like kinase family of serine/threonine kinases that are critical regulators of cell cycle progression, mitosis, cytokinesis, and the DNA damage response. Members of this family are characterized by an amino-terminal kinase domain and a carboxy-terminal bipartite polo box domain that functions as a substrate-binding motif and a cellular localization signal. This gene has also been implicated in stress responses and double-strand break repair. In human cell lines, this protein is reported to associate with centrosomes in a microtubule-dependent manner, and during mitosis, the protein becomes localized to the mitotic apparatus.
Molecular Description
Protein ClassificationTransferase
Structure Weight32791.14 Da
Polymer1
MoleculeSERINE/THREONINE-PROTEIN KINASE PLK3
Chain Length281 amino acids
Crystal Description
PDB ID4B6L
MMDB ID112743
SourceSpodoptera frugiperda
MethodX-Ray Diffraction
Resolution1.90 Å
Ligand Chemical ComponentSULFATE ION, 9ZP
Gene Information
Gene NamePLK3
SynonymsCNK; FNK; PRK; PLK-3
UniProt IDQ9H4B4
Gene ID1263
Chromosome Location1p34.1
FunctionATP binding; p53 binding; protein serine/threonine kinase activity
Reference
Reference Brown K, Charrier JD, Durrant S, Griffiths M, Hudson C, Kay D, Knegtel R, Odonnell M, Pierard F, Twin H, Weber P, Young S. Discovery of oral polo-like kinase (Plk) inhibitors with enhanced selectivity profile using residue targeted drug design. No recorded citation in PubMed

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