PLK3

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PLK3 Protein Crystal(CBCRY55)

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Product Summary
Name	PLK3 Protein Crystal Download Datasheet

Background
Background	Polo-like kinase 3 (PLK3) is a member of the highly conserved polo-like kinase family of serine/threonine kinases that are critical regulators of cell cycle progression, mitosis, cytokinesis, and the DNA damage response. Members of this family are characterized by an amino-terminal kinase domain and a carboxy-terminal bipartite polo box domain that functions as a substrate-binding motif and a cellular localization signal. This gene has also been implicated in stress responses and double-strand break repair. In human cell lines, this protein is reported to associate with centrosomes in a microtubule-dependent manner, and during mitosis, the protein becomes localized to the mitotic apparatus.

Background

Polo-like kinase 3 (PLK3) is a member of the highly conserved polo-like kinase family of serine/threonine kinases that are critical regulators of cell cycle progression, mitosis, cytokinesis, and the DNA damage response. Members of this family are characterized by an amino-terminal kinase domain and a carboxy-terminal bipartite polo box domain that functions as a substrate-binding motif and a cellular localization signal. This gene has also been implicated in stress responses and double-strand break repair. In human cell lines, this protein is reported to associate with centrosomes in a microtubule-dependent manner, and during mitosis, the protein becomes localized to the mitotic apparatus.

Molecular Description
Protein Classification	Transferase
Structure Weight	32791.14 Da
Polymer	1
Molecule	SERINE/THREONINE-PROTEIN KINASE PLK3
Chain Length	281 amino acids

Crystal Description
PDB ID	4B6L
MMDB ID	112743
Source	Spodoptera frugiperda
Method	X-Ray Diffraction
Resolution	1.90 Å
Ligand Chemical Component	SULFATE ION, 9ZP

Gene Information
Gene Name	PLK3
Synonyms	CNK; FNK; PRK; PLK-3
UniProt ID	Q9H4B4
Gene ID	1263
Chromosome Location	1p34.1
Function	ATP binding; p53 binding; protein serine/threonine kinase activity

Reference
Reference	Brown K, Charrier JD, Durrant S, Griffiths M, Hudson C, Kay D, Knegtel R, Odonnell M, Pierard F, Twin H, Weber P, Young S. Discovery of oral polo-like kinase (Plk) inhibitors with enhanced selectivity profile using residue targeted drug design. No recorded citation in PubMed

PLK3 Protein Crystal

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PLK3 Protein Crystal(CBCRY55)

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