Background

Polo-like kinase 3 (PLK3) is a member of the highly conserved polo-like kinase family of serine/threonine kinases that are critical regulators of cell cycle progression, mitosis, cytokinesis, and the DNA damage response. Members of this family are characterized by an amino-terminal kinase domain and a carboxy-terminal bipartite polo box domain that functions as a substrate-binding motif and a cellular localization signal. This gene has also been implicated in stress responses and double-strand break repair. In human cell lines, this protein is reported to associate with centrosomes in a microtubule-dependent manner, and during mitosis, the protein becomes localized to the mitotic apparatus.

Protein Classification

Transferase

Structure Weight

32791.14 Da

Polymer

1

Molecule

SERINE/THREONINE-PROTEIN KINASE PLK3

Chain Length

281 amino acids

PDB ID

4B6L

MMDB ID

112743

Source

Spodoptera frugiperda

Method

X-Ray Diffraction

Resolution

1.90 Å

Ligand Chemical Component

SULFATE ION, 9ZP

Gene Name

PLK3

Synonyms

CNK; FNK; PRK; PLK-3

UniProt ID

Q9H4B4

Gene ID

1263

Chromosome Location

1p34.1

Function

ATP binding; p53 binding; protein serine/threonine kinase activity

Reference

Brown K, Charrier JD, Durrant S, Griffiths M, Hudson C, Kay D, Knegtel R, Odonnell M, Pierard F, Twin H, Weber P, Young S. Discovery of oral polo-like kinase (Plk) inhibitors with enhanced selectivity profile using residue targeted drug design. No recorded citation in PubMed