Daunorubicin/Vincristine (10/1, mol/mol) Loaded Liposomes(Lipo-020RG)

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Product Summary
Name Daunorubicin/Vincristine (10/1, mol/mol) Loaded Liposomes
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Cat No.Lipo-020RG
Product OverviewDaunorubicin HCl (Daunomycin, RP 13057, Rubidomycin) inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 ?M in a cell-free assay. Daunorubicin is a topoisomerase II inhibitor that induces apoptosis. Vincristine sulfate (NSC-67574, Leurocristine, Oncovin, 22-Oxovincaleukoblastine) is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 ?M in a cell-free assay. Vincristine sulfate induces apoptosis. This product is a PEG modified pre-formulated liposome with daunorubicin HCl and vincristine sulfate at a 10/1 (mol/mol) ratio loaded. The liposomes are useful for the study of ratiometric dosing with chemotherapeutic agents in preclinical models of cancer, suitable for use in vitro or in vivo studies. The lipid composition is HSPC/Chol/DSPE-mPEG2000 (56.2/38.5/5.3, mol/mol).
Lipid CompositionHSPC/Chol/DSPE-mPEG2000 (56.2/38.5/5.3, mol/mol)
Active IngredientsDaunorubicin; Vincristine
FormLiquid
Storage Buffer154 mM NaCl, pH 5.5
Concentration1.4 mg/mL (Concentration Daunorubicin); 219 μg/mL (Concentration Vincristine); Lipid Concentration 30 mM
Stability6 months
Storage2 °C to 8 °C (do not freeze)

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  • Can you provide information on the size and composition of your liposomes?

    Yes, we offer detailed specifications for each product, enabling researchers to select liposomes that best match their experimental requirements.

  • Do you offer customization options for liposome formulations?

    Yes, we offer customization services to meet the unique demands of research projects. Our team of experts can work with customers to develop custom liposome formulations tailored to their specific needs, ensuring optimal results for their experiments.

  • What analytical and characterization data do you provide with your liposome products?

    We provide comprehensive analytical and characterization data for all our liposome products, such as size distribution, zeta potential, and encapsulation efficiency.

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